Free Radicals in ENT Pathology

  • Josef Miller
  • Colleen G. Le Prell
  • Leonard Rybak

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Josef Miller, Colleen G. Le Prell, Leonard P. Rybak
      Pages 3-6
  3. Basic Science of Free Radical Biology in ENT

    1. Front Matter
      Pages 7-7
    2. Jinze Xu, Christiaan Leeuwenburgh
      Pages 9-20
    3. Najeeb A. Shirwany, Michael D. Seidman
      Pages 57-89
  4. Epidemiology of Hearing Loss

    1. Front Matter
      Pages 91-91
    2. Christopher Spankovich
      Pages 111-126
  5. Oxidative Stress and Noise-Induced Hearing Loss

    1. Front Matter
      Pages 127-127
    2. Richard A. Altschuler, David Dolan
      Pages 129-146
    3. Daisuke Yamashita
      Pages 147-161
  6. Oxidative Stress and Drug-Induced Hearing Loss

    1. Front Matter
      Pages 193-193
    2. Leonard P. Rybak, Michael J. Brenner
      Pages 195-216
    3. Göran Laurell, Pernilla Videhult Pierre
      Pages 217-241
    4. Jill M. Anderson, Kathleen Campbell
      Pages 243-269
  7. Oxidative Stress and Age-Related Hearing Loss

    1. Front Matter
      Pages 271-271
    2. Mi-Jung Kim, Karessa White, Logan Walker, Chul Han, Shinichi Someya
      Pages 273-288
    3. Robert D. Frisina, D. Robert Frisina
      Pages 289-304
    4. Pedro Melgar-Rojas, Juan C. Alvarado, Verónica Fuentes-Santamaría, José M. Juiz
      Pages 305-333
    5. Tatsuya Yamasoba
      Pages 335-349
  8. Hereditary Hearing Loss

    1. Front Matter
      Pages 351-351
    2. Glenn Green, Yehoash Raphael
      Pages 377-391
  9. Cochlear Implants, Radiation, Trauma and Other Stress Factors

    1. Front Matter
      Pages 393-393
    2. Thomas Lenarz, Verena Scheper
      Pages 423-442
    3. Wong-Kein Christopher Low, Russel Kahmke, Debara L. Tucci
      Pages 443-454
  10. Head and Neck

    1. Front Matter
      Pages 455-455
    2. Carter Van Waes
      Pages 457-466
    3. Muzaffer Kanlikama, Elif Baysal
      Pages 467-477
    4. Vaclav Holecek, Richard Rokyta, Jaroslav Slipka
      Pages 479-492
  11. Conclusion

    1. Front Matter
      Pages 493-493
    2. Colleen G. Le Prell, Leonard P. Rybak, Richard A. Altschuler, Thomas Lenarz, Josef Miller
      Pages 495-502
  12. Josef Miller, Colleen G. Le Prell, Leonard Rybak
    Pages E1-E1
  13. Back Matter
    Pages 503-507

About this book


This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and “white paper” that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently,  new interventions to medically treat ENT pathology.


Cochlear implants Hearing Mitochondrial deafness Noise-induced Sleep apnea

Editors and affiliations

  • Josef Miller
    • 1
  • Colleen G. Le Prell
    • 2
  • Leonard Rybak
    • 3
  1. 1.Cochlear Signaling & Tissue Engin.University of Michigan Kresge Hearing Research InstituteAnn ArborUSA
  2. 2.Dept of Speech , Lang & Hearing SciUniv of Florida Health Sciences CenterGainesvilleUSA
  3. 3.Div . of Otolaryngology Head & Neck SurgerySIU School of MedicineSpringfieldUSA

Bibliographic information