© 2015

A Tissue Regeneration Approach to Bone and Cartilage Repair

  • Hala Zreiqat
  • Colin R. Dunstan
  • Vicki Rosen

Part of the Mechanical Engineering Series book series (MES)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Takenobu Katagiri, Sho Tsukamoto, Kenji Osawa, Shoichiro Kokabu
    Pages 1-15
  3. Di Chen, Shan Li, Tian-Fang Li
    Pages 17-37
  4. Gerald J. Atkins, Matthew Prideaux, David M. Findlay
    Pages 39-52
  5. Walid Zaher, Adiba Isa, Moustapha Kassem
    Pages 53-63
  6. Sina Nassiri, Pamela Graney, Kara L. Spiller
    Pages 65-84
  7. Ulf M. E. Wikesjö, Cristiano Susin, Jaebum Lee
    Pages 99-118
  8. ZuFu Lu, Jiao Jiao Li, Hala Zreiqat
    Pages 119-146
  9. Xinquan Jiang, Zhiyuan Zhang
    Pages 167-190
  10. Henning Madry, Magali Cucchiarini
    Pages 219-228
  11. Gundula Schulze-Tanzil
    Pages 229-254

About this book


Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration.

Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues.

This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.


Biomaterials Bone Regeneration Bone Tissue Engineering Critical Size Defects Principles of Tissue Engineering Stem Cells in Tissue Regeneration

Editors and affiliations

  • Hala Zreiqat
    • 1
  • Colin R. Dunstan
    • 2
  • Vicki Rosen
    • 3
  1. 1.Tissue Engineering and Biomaterials Research UnitUniversity of SydneySydneyAustralia
  2. 2.Biomedical EngineeringUniversity of SydneySydneyAustralia
  3. 3.Department of Developmental BiologyHarvard School of Dental MedicineBostonUSA

About the editors

Hala Zreiqat is expert in developing biomaterials for bone/cartilage tissue repair and regeneration and the in vivo/in vitro assessment of cell-biomaterial interaction.

Colin Dunstan is an expert in bone cell biology and the interrelationships between bone cells and their microenvironment.

Vicki Rosen is an expert is studying the physiological roles that bone morphogenetic proteins (BMPs) play in the development, maintenance, and repair of musculoskeletal tissues (bone, cartilage, tendon, ligament, meniscus, muscle).

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods
Materials & Steel