© 2015

Resistance to Photodynamic Therapy in Cancer

  • Valentina Rapozzi
  • Giulio Jori


  • Explores mechanisms of action in PDT, the relationship between PDT cytotoxicity and cellular changes

  • Discusses the development of new technological advances in PDT for cancer

  • Offers strategic approaches to reduce multi-drug resistance of tumor cells by PDT


Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 5)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Valentina Rapozzi, Giulio Jori
      Pages 3-26
  3. Mechanistic Aspects Involved in Resistance to PDT

    1. Front Matter
      Pages 27-27
    2. Adriana Casas, Christian Perotti, Gabriela Di Venosa, Alcira Batlle
      Pages 29-63
    3. Shannon M. Gallagher‐Colombo, Jarod C. Finlay, Theresa M. Busch
      Pages 65-97
    4. A Zamarrón, S Lucena, N Salazar, P Jaén, S González, Y Gilaberte et al.
      Pages 117-145
  4. Specific Strategies to Sensitize Tumor Cells to PDT

    1. Front Matter
      Pages 147-147
    2. Malgorzata Firczuk, Magdalena Gabrysiak, Jakub Golab
      Pages 149-161
    3. Viviana A. Rivarola, Ingrid Sol Cogno
      Pages 163-182
    4. Marian Luna, Angela Ferrario, Natalie Rucker, Emma Balouzian, Sam Wong, Sophie Mansfield et al.
      Pages 183-193
  5. Approaches to Reduce the Multi-Drug Resistance of Tumor Cells by PDT

    1. Front Matter
      Pages 195-195
    2. Magali Toussaint, Muriel Barberi-Heyob, Sophie Pinel, Céline Frochot
      Pages 197-211
    3. Zvi Malik, Abraham Nudelman, Benjamin Ehrenberg
      Pages 213-228
    4. Sulbha K Sharma, Ying-Ying Huang, Michael R Hamblin
      Pages 229-246
  6. Valentina Rapozzi, Giulio Jori
    Pages E1-E1
  7. Back Matter
    Pages 247-248

About this book


This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.


PDT oxygen reactive species photosensitizers phototherapy and cancer tumor cells

Editors and affiliations

  • Valentina Rapozzi
    • 1
  • Giulio Jori
    • 2
  1. 1.Medical and Biological SciencesUniversity of UdineUdineItaly
  2. 2.Prof. GhirettiUniversita Padova Ist. Biologia AnimalePadovaItaly

About the editors

Giulio Jori is Professor of Biophysics at the University of Padova, Italy. He has been a founding member and President of the European Society for Photobiology. His research interests are focused on basic mechanisms of photodynamic action at a cellular and tissue level, as well as investigations concerning the application of photodynamic therapy for the treatment of tumours and microbial infections. Dr. Jori is Editor-in-chief of Journal of Photochemistry and Photobiology and he was also chairman of the ownership board of the journal Photochemical and Photobiological Sciences. He has been the chief organizer of nine International Symposia on Photodynamic Therapy and Photodiagnosis in Clinical Practice. In addition, he has received an award for excellence in research from the European Society for Photobiology.

Valentina Rapozzi is a Researcher at the University of Udine, Italy. Dr. Rapozzi's research is focused on the antitumoral molecular pathways in photodynamic therapy. She is a member of the European Society for Photobiology, and a member of the Council of the Italian Society of Photobiology.

Bibliographic information

  • Book Title Resistance to Photodynamic Therapy in Cancer
  • Editors Valentina Rapozzi
    Giulio Jori
  • Series Title Resistance to Targeted Anti-Cancer Therapeutics
  • Series Abbreviated Title Resistance to Targeted Anti-Cancer Therapeutics
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-12729-3
  • Softcover ISBN 978-3-319-38175-6
  • eBook ISBN 978-3-319-12730-9
  • Series ISSN 2196-5501
  • Series E-ISSN 2196-551X
  • Edition Number 1
  • Number of Pages XV, 248
  • Number of Illustrations 12 b/w illustrations, 36 illustrations in colour
  • Topics Cancer Research
    Drug Resistance
    Molecular Medicine
  • Buy this book on publisher's site
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