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Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

  • Heiko Braak
  • Kelly Del Tredici

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 215)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Heiko Braak, Kelly Del Tredici
    Pages 1-2
  3. Heiko Braak, Kelly Del Tredici
    Pages 3-14
  4. Heiko Braak, Kelly Del Tredici
    Pages 21-24
  5. Heiko Braak, Kelly Del Tredici
    Pages 25-36
  6. Heiko Braak, Kelly Del Tredici
    Pages 57-73
  7. Heiko Braak, Kelly Del Tredici
    Pages 75-93
  8. Heiko Braak, Kelly Del Tredici
    Pages 131-133
  9. Heiko Braak, Kelly Del Tredici
    Pages 135-139
  10. Back Matter
    Pages 141-162

About this book

Introduction

As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.

Keywords

amyloid precursor protein argyophilic lesions neurofibrillary changes non-Alzheimer disorder plaque-like formations tauopathies

Authors and affiliations

  • Heiko Braak
    • 1
  • Kelly Del Tredici
    • 2
  1. 1.Zentrum f. Biomed. Forschung AG, Klinische Neuroanatomie/Abteilung NeurologieUniversität UlmUlmGermany
  2. 2.Zentrum f. Biomed. Forschung AG, Klinische Neuroanatomie/Abteilung NeurologieUniversität UlmUlmGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-12679-1
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-12678-4
  • Online ISBN 978-3-319-12679-1
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • Buy this book on publisher's site
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