The NeuroMuscular System: From Earth to Space Life Science

Neuromuscular Cell Signalling in Disuse and Exercise

  • Dieter Blottner
  • Michele Salanova

Part of the SpringerBriefs in Space Life Sciences book series (BRIEFSSLS)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Dieter Blottner, Michele Salanova
    Pages 1-7
  3. Dieter Blottner, Michele Salanova
    Pages 9-62
  4. Dieter Blottner, Michele Salanova
    Pages 63-87
  5. Dieter Blottner, Michele Salanova
    Pages 89-92

About this book


The book provides fundamental new insights in the structure and function of the healthy  NeuroMuscular system. Recent findings suggest that the musculoskeletal system that supports movement control on Earth is controlled by unique principles of structural, biochemical and molecular characteristics. Mechanical loading by working against normal gravity helps to support principal structures in bone, muscle and associated subcellular scaffold components. Disuse or immobilization of the body in bed rest on Earth or in microgravity in Space result in considerable loss of bone, muscle and force with downregulation of neuromuscular activity resulting in impaired performance control. The goal is to develop exercise prescriptions to maintain postural control in normal life, aging and rehabilitation on Earth as well as for an adequate human performance management in Space.


Skeletal Muscle effect of gravity on human physiology exercise countermeasure muscle atrophy neuromuscular junctions

Authors and affiliations

  • Dieter Blottner
    • 1
  • Michele Salanova
    • 2
  1. 1.Vegetative AnatomyCharité Universitätsmedizin BerlinBerlinGermany
  2. 2.Vegetative AnatomyCharité Universitätsmedizin BerlinBerlinGermany

Bibliographic information

  • DOI
  • Copyright Information The Author(s) 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-12297-7
  • Online ISBN 978-3-319-12298-4
  • Series Print ISSN 2196-5560
  • Series Online ISSN 2196-5579
  • Buy this book on publisher's site
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