© 2015

Genomic Instability and Cancer Metastasis

Mechanisms, Emerging Themes, and Novel Therapeutic Strategies

  • Chris Maxwell
  • Cal Roskelley

Part of the Cancer Metastasis - Biology and Treatment book series (CMBT, volume 20)

Table of contents

  1. Front Matter
    Pages i-x
  2. David I. Rodenhiser, Ann F. Chambers
    Pages 1-13
  3. Mohamed E. Ashour, Lamia El-Shafie, Sherif F. El-Khamisy
    Pages 39-74
  4. Jonathan Tang, Walter Georgescu, Thomas Deschamps, Steven M. Yannone, Sylvain V. Costes
    Pages 75-93
  5. Dawn R Cochrane, Dong Lin, Graham Dellaire, Elizabeth C Halvorsen, Jason N Berman, Yuzhou Wang et al.
    Pages 95-123
  6. Calvin D. Roskelley
    Pages 125-137
  7. Allison K. Simi, Alexandra S. Piotrowski, Celeste M. Nelson
    Pages 139-158
  8. Gregor Reid
    Pages 159-177
  9. Alexandra M. N. Hauser-Kawaguchi, Leonard G. Luyt
    Pages 205-244
  10. Back Matter
    Pages 245-247

About this book


Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1  outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.


Cancer Metastasis DNA damage response Genomic instability Therapeutic approaches Tumor heterogeneity

Editors and affiliations

  • Chris Maxwell
    • 1
  • Cal Roskelley
    • 2
  1. 1.Child & Family Research InstituteUniversity of British Columbia, PediatricsVancouverCanada
  2. 2.Dept of Cellular & Physiological SciencesUniversity of British Columbia, Dept. of Cellular & Physiological SciencesVancouverCanada

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology
Consumer Packaged Goods


“This book connects cancer metastasis, the major cause of death in patients with malignancy, with genomic instability. For oncologists and biologists.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (4), 2015)