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Recent Advances in Prolactin Research

  • Maria Diakonova, PhD

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 846)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Nira Ben-Jonathan, Eric Hugo
    Pages 1-35
  3. Allyson K. Booth, Arthur Gutierrez-Hartmann
    Pages 37-59
  4. Carmen Clapp, Stéphanie Thebault, Yazmín Macotela, Bibiana Moreno-Carranza, Jakob Triebel, Gonzalo Martínez de la Escalera
    Pages 83-95
  5. P. R. Le Tissier, D. J. Hodson, A. O. Martin, N. Romanò, P. Mollard
    Pages 139-162
  6. Jorge Martín-Pérez, José Manuel García-Martínez, María Pilar Sánchez-Bailón, Víctor Mayoral-Varo, Annarica Calcabrini
    Pages 163-188
  7. Kathleen A. O’Leary, Michael P. Shea, Linda A. Schuler
    Pages 201-220
  8. Lucila Sackmann-Sala, Vincent Goffin
    Pages 221-242
  9. Ana Laura Pereira Suarez, Gonzalo López-Rincón, Priscila A. Martínez Neri, Ciro Estrada-Chávez
    Pages 243-264
  10. Maria Diakonova
    Pages E1-E2
  11. Back Matter
    Pages 281-281

About this book

Introduction

Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions.

Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.

Keywords

Cytokine Pituitary Prolactin breast cancer signaling pathways

Editors and affiliations

  • Maria Diakonova, PhD
    • 1
  1. 1.Department of Biological SciencesUniversity of ToledoToledoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-12114-7
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-12113-0
  • Online ISBN 978-3-319-12114-7
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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