Drug Treatment of Sleep Disorders

  • Antonio Guglietta

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages i-viii
  2. General Concepts

    1. Front Matter
      Pages 1-1
    2. Chiara Berteotti, Matteo Cerri, Marco Luppi, Alessandro Silvani, Roberto Amici
      Pages 3-23
    3. Michael Thorpy
      Pages 71-83
  3. Drugs to Treat Insomnia

    1. Front Matter
      Pages 109-109
    2. Dimitri Markov, Karl Doghramji
      Pages 111-119
    3. Fabiana d’ Aniello, Benjamin Santos, Antonio Guglietta
      Pages 121-145
    4. Luc Staner
      Pages 147-157
    5. Alberto K. De la Herrán-Arita, Ana C. Equihua-Benítez, René Drucker-Colín
      Pages 191-207
  4. Drugs to Treat Excessive Daytime Sleepiness

    1. Front Matter
      Pages 209-209
    2. Karel Šonka, Peter Šóš, Marek Susta
      Pages 211-229
    3. Ahmed S. BaHammam, David Nelson Neubauer, Seithikurippu R. Pandi-Perumal
      Pages 231-248
    4. Oscar Arias-Carrión
      Pages 249-258
  5. Drugs to Treat Circadian Sleep Disorders

    1. Front Matter
      Pages 259-259
    2. David N. Neubauer, Ahmed S. BaHammam, Seithikurppu R. Pandi-Perumal
      Pages 261-269
  6. Conclusive Remarks

  7. Back Matter
    Pages 289-297

About this book


Following reviews on sleep physiology, regulation, pharmacology, and the neuronal networks regulating sleep and awakening, as well as a classification of sleep disorders, this book presents a number of major breakthroughs in the treatment of those disorders. These include recently approved drugs for treating insomnia, such as Doxepin; variations on previously approved molecules, e.g. Zolpidem sublingual preparation; or new chemical entities in advanced stages of clinical development, e.g. Orexin antagonists. Further topics discussed include drugs acting on the GABA receptor, such as Lorediplon and Eszopiclone; the treatment of excessive daytime drowsiness with cell therapy and drugs such as Modafinil, Armodafinil and Sodium oxybate; and the use of Tasimelteon in the treatment of circadian sleep disorders.


Drugs acting on the GABA receptor Excessive daytime sleepiness Hypnotics Insomnia Narcolepsy

Editors and affiliations

  • Antonio Guglietta
    • 1
  1. 1.Independent Pharmaceutical ConsultantBarcelonaSpain

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-11513-9
  • Online ISBN 978-3-319-11514-6
  • Series Print ISSN 2296-6056
  • Series Online ISSN 2296-6064
  • Buy this book on publisher's site
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