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ADAMTS13

Biology and Disease

  • George M. Rodgers
Book

Table of contents

  1. Front Matter
    Pages i-x
  2. Suneel S. Apte
    Pages 21-37
  3. X. Long Zheng
    Pages 39-57
  4. Manfai Lee, George M. Rodgers
    Pages 59-72
  5. Yoshihiro Fujimura, Koichi Kokame, Hideo Yagi, Ayami Isonishi, Masanori Matsumoto, Toshiyuki Miyata
    Pages 73-90
  6. Kristi J. Smock, Nahla M. Heikal
    Pages 141-158
  7. Silvia Ferrari, Hanspeter Rottensteiner, Friedrich Scheiflinger
    Pages 159-184
  8. Back Matter
    Pages 185-186

About this book

Introduction

This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.

 

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.

Keywords

Angiogenesis Protease Thrombosis Upshaw-Schulman Von Willebrand

Editors and affiliations

  • George M. Rodgers
    • 1
  1. 1.Division of HematologyUniversity of Utah Health Sciences CenterSalt Lake CityUSA

Bibliographic information

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