Advertisement

Fc Receptors

  • Marc Daeron
  • Falk Nimmerjahn

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 382)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Old and New FcRs

    1. Front Matter
      Pages 1-1
    2. Hiromi Kubagawa, Yoshiki Kubagawa, Dewitt Jones, Tahseen H. Nasti, Mark R. Walter, Kazuhito Honjo
      Pages 3-28
    3. F. J. Li, W. J. Won, E. J. Becker Jr., J. L. Easlick, E. M. Tabengwa, R. Li et al.
      Pages 29-50
  3. FcR Signaling

    1. Front Matter
      Pages 67-67
    2. Anna Niarakis, Yacine Bounab, Luca Grieco, Romain Roncagalli, Anne-Marie Hesse, Jérôme Garin et al.
      Pages 69-93
    3. Tarik Attout, Andres Floto, Pierre Launay
      Pages 95-110
    4. Marcel Kuhny, Carolin N. Zorn, Michael Huber
      Pages 111-127
  4. FcR Biology

    1. Front Matter
      Pages 129-129
    2. Marc Daëron
      Pages 131-164
    3. Jerrard M. Hayes, Eoin F. J. Cosgrave, Weston B. Struwe, Mark Wormald, Gavin P. Davey, Roy Jefferis et al.
      Pages 165-199
    4. Birgitta Heyman
      Pages 201-219
    5. Sanae Ben Mkaddem, Ivy Christou, Elisabetta Rossato, Laureline Berthelot, Agnès Lehuen, Renato C. Monteiro
      Pages 221-235
    6. Stylianos Bournazos, David J. DiLillo, Jeffrey V. Ravetch
      Pages 237-248
    7. Dilip K. Challa, Ramraj Velmurugan, Raimund J. Ober, E. Sally Ward
      Pages 249-272
  5. FcRs and Disease

    1. Front Matter
      Pages 273-273
    2. Xinrui Li, Andrew W. Gibson, Robert P. Kimberly
      Pages 275-302
    3. Hanane el Bannoudi, Andreea Ioan-Facsinay, René E. M. Toes
      Pages 303-319
  6. FcRs and Therapeutic Antibodies

    1. Front Matter
      Pages 353-353
    2. Ann L. White, Stephen A. Beers, Mark S. Cragg
      Pages 355-372
    3. Jantine E. Bakema, Marjolein van Egmond
      Pages 373-392
  7. Back Matter
    Pages 419-424

About this book

Introduction

This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.

Keywords

Agonist antibodies Calcium channels Fc receptors FcR FcR signaling Glycosylation Humanized mice Lipid phosphatases Rheumatoid arthritis

Editors and affiliations

  • Marc Daeron
    • 1
  • Falk Nimmerjahn
    • 2
  1. 1.Institut PasteurParisFrance
  2. 2.Department of BiologyInstitute of Genetics, University of Erlangen-NürnbergErlangenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-07911-0
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-07910-3
  • Online ISBN 978-3-319-07911-0
  • Series Print ISSN 0070-217X
  • Series Online ISSN 2196-9965
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods