Statistical Analysis of Next Generation Sequencing Data

Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized medicine.

About the editors:

Somnath Datta is Professor and Vice Chair of Bioinformatics and Biostatistics at the University of Louisville. He is Fellow of the American Statistical Association, Fellow of the Institute of Mathematical Statistics and Elected Member of the International Statistical Institute. He has contributed to numerous research areas in Statistics, Biostatistics and Bioinformatics.

Dan Nettleton is Professor and Laurence H. Baker Endowed Chair of Biological Statistics in the Department of Statistics at Iowa State University.  He is Fellow of the American Statistical Association and has published research on a variety of topics in statistics, biology and bioinformatics.

• Copy Number Variation
• DNA
• Genomics
• Isoform Expression Detection
• RNA
• Sequencing Data

From the book reviews:

“This book is an excellent collection of 20 chapters presenting the state of art (as of 2014) of algorithms developed for the analysis of next generation sequencing (NGS) data. … This book is a valuable and well-timed collection of articles on the statistical methods that can be applied on NGS data. Even if no prior NGS knowledge is required, the book is addressed mainly to researchers at postgraduate and post-doc levels.” (Irina Ioana Mohorianu, zbMATH, Vol. 1297, 2014)

• Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, USA

  Somnath Datta

• Department of Statistics, Iowa State University, Ames, USA

  Dan Nettleton

About the editors:

Somnath Datta is Professor and Vice Chair of Bioinformatics and Biostatistics at the University of Louisville. He is Fellow of the American Statistical Association, Fellow of the Institute of Mathematical Statistics, and Elected Member of the International Statistical Institute. He has contributed to numerous research areas in Statistics, Biostatistics and Bioinformatics.

Dan Nettleton is Professor and Laurence H. Baker Endowed Chair of Biological Statistics in the Department of Statistics at Iowa State University.  He is Fellow of the American Statistical Association and has published research on a variety of topics in statistics, biology, and bioinformatics.

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