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Modelling the Short QT Syndrome Gene Mutations

And Their Role in Cardiac Arrhythmogenesis

  • Ismail Adeniran

Part of the Springer Theses book series (Springer Theses)

About this book

Introduction

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases. 
The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as “outstanding.”

Keywords

3D Virtual Heart Arrhythmia Simulation with Virtual Heart Gene Mutations Inducing Heart Arrhythmia Human Ventricles Markov Models Multiphysics Models of Heart Arrhythmia Potassium Channels and Heart Arrhythmia Short QT Syndrome Stretch-activated Channel Ventricular Arryhthmias Ventricular Fibrillation

Authors and affiliations

  • Ismail Adeniran
    • 1
  1. 1.Biological Physics Group School of Physics and AstronomyUniversity of ManchesterManchesterUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-07200-5
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-319-07199-2
  • Online ISBN 978-3-319-07200-5
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site
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