Sickle Cell Anemia

From Basic Science to Clinical Practice

  • Fernando Ferreira Costa
  • Nicola Conran

Table of contents

  1. Front Matter
    Pages i-xv
  2. Susan E. Jorge, Daniela M. Ribeiro, Magnun N. N. Santos, Maria de Fátima Sonati
    Pages 1-22
  3. Frédéric B. Piel, Thomas N. Williams
    Pages 23-47
  4. Martin H. Steinberg
    Pages 49-73
  5. Nancy J. Wandersee, Cheryl A. Hillery
    Pages 75-90
  6. Dachuan Zhang, Paul S. Frenette
    Pages 91-107
  7. Marina Pereira Colella, Erich Vinicius de Paula, Margareth Castro Ozelo, Fabiola Traina
    Pages 109-127
  8. Camila Bononi de Almeida, Gregory J. Kato, Nicola Conran
    Pages 177-211
  9. Robert Sheppard Nickel, Lewis L. Hsu
    Pages 213-229
  10. Rouba Abdennour, Miguel R. Abboud
    Pages 231-267
  11. Mário A. Claudino, Carla F. Franco Penteado, Kleber Yotsumoto Fertrin
    Pages 269-283
  12. Fernando Ferreira Costa, Kleber Yotsumoto Fertrin
    Pages 285-318
  13. Kate Gardner, Swee Lay Thein
    Pages 371-397
  14. Kerri Nottage, Jeremie Estepp, Jane Hankins
    Pages 399-429
  15. Back Matter
    Pages 431-435

About this book


Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.


Hematology Hemoglobin Hereditary Disease Red Cells Sickle Cell Anemia

Editors and affiliations

  • Fernando Ferreira Costa
    • 1
  • Nicola Conran
    • 2
  1. 1.Centro de Hematologia e HemoterapiaUnicampCampinasBrazil
  2. 2.Centro de Hematologia e HemoterapiaUnicampCampinasBrazil

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-06712-4
  • Online ISBN 978-3-319-06713-1
  • Buy this book on publisher's site
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