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© 2014

Peptide and Protein Interaction with Membrane Systems

Applications to Antimicrobial Therapy and Protein Drug Delivery

  • Nominated as an outstanding Ph.D. thesis by the University of Rome Tor Vergata, Italy

  • Selected as the as the best Italian Ph.D. Physical Chemistry Thesis 2012-2013 by the Italian Chemical Society

  • Provides a comprehensive but accessible introduction to both antimicrobial peptides and protein-based drugs: two hot areas in biomolecular pharmaceutics

  • Presents numerous examples of the use of fluorescence spectroscopy to characterize peptide and protein interaction with lipid membranes, which provide a good starting point for the novice in this field

Book
  • 5.1k Downloads

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Antimicrobial Peptides: Mechanism of Action, Selectivity and Biological Activity

    1. Front Matter
      Pages 1-1
    2. Sara Bobone
      Pages 3-10
    3. Sara Bobone
      Pages 11-17
    4. Sara Bobone
      Pages 19-27
    5. Sara Bobone
      Pages 29-90
  3. Hydrogel Nanoparticles for Enzyme-Based Therapies

    1. Front Matter
      Pages 91-91
    2. Sara Bobone
      Pages 93-102
    3. Sara Bobone
      Pages 103-110
    4. Sara Bobone
      Pages 111-133
  4. Back Matter
    Pages 135-140

About this book

Introduction

In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self-
assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nanodevices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.

Keywords

Enzyme Encapsulation Fluorescence Spectroscopy Mechanism of Action of Antimicrobial Peptides Peptide-Membrane Interactions Protein Drug Delivery Selectivity of Antimicrobial Peptides

Authors and affiliations

  1. 1.Department of Chemical Sciences and TechnolgiesUniversity of Rome Tor VergataRomeItaly

About the authors

I received my M.Sc. Degree in Chemistry magna cum laude from the University of Rome "Sapienza". After the degree, I moved to Tor Vergata, where I won a fellowship for PhD students in Chemical Sciences, under the supervision of Prof. L. Stella. I defended my thesis in 2013 and then continued my work as a postdoctoral fellow. The thesis was awarded the 2012-2013 "Premio Semerano" by the Italian Chemical Society, as the best Italian PhD Physical Chemistry Thesis. The thesis work led to the publication of 7 papers on international journals and to the participation to 13 international and national conferences.

Bibliographic information

  • Book Title Peptide and Protein Interaction with Membrane Systems
  • Book Subtitle Applications to Antimicrobial Therapy and Protein Drug Delivery
  • Authors Sara Bobone
  • Series Title Springer Theses
  • Series Abbreviated Title Springer Theses
  • DOI https://doi.org/10.1007/978-3-319-06434-5
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science Chemistry and Material Science (R0)
  • Hardcover ISBN 978-3-319-06433-8
  • Softcover ISBN 978-3-319-38273-9
  • eBook ISBN 978-3-319-06434-5
  • Series ISSN 2190-5053
  • Series E-ISSN 2190-5061
  • Edition Number 1
  • Number of Pages XIII, 140
  • Number of Illustrations 76 b/w illustrations, 18 illustrations in colour
  • Topics Analytical Chemistry
    Protein Science
    Drug Resistance
  • Buy this book on publisher's site
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