© 2014

Advancements of Mass Spectrometry in Biomedical Research

  • Alisa G. Woods
  • Costel C. Darie


  • Covers therapeutic fields utilizing mass spectrometry and proteomic discovery, including the newest field, psychiatry

  • Discusses the most recent proteomic methodology as well as innovative approaches to protein separation that increase the power of this technique

  • Describes how researchers unfamiliar with mass spectrometry may partner with proteomic scientists most optimally to enhance their own work


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 806)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel et al.
    Pages 1-32
  3. Lee A. Gethings, Joanne B. Connolly
    Pages 59-77
  4. Esthelle Hoedt, Guoan Zhang, Thomas A. Neubert
    Pages 93-106
  5. Urmi Roy, Alisa G. Woods, Izabela Sokolowska, Costel C. Darie
    Pages 107-128
  6. Hanna G. Budayeva, Ileana M. Cristea
    Pages 263-282
  7. Carly N. Ferguson, Joseph W. M. Fowler, Jonathan F. Waxer, Richard A. Gatti, Joseph A. Loo
    Pages 283-299
  8. Karina Ckless
    Pages 301-317
  9. Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, Kenneth N. Wallace
    Pages 331-340
  10. Ronald A. Miller, Daniel S. Spellman
    Pages 341-359
  11. Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, Alina Vasilescu
    Pages 361-382
  12. Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, Kathleen F. Arcaro
    Pages 399-408

About this book


This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field.

Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.


biomarkers mass spectrometry protein separation proteomics

Editors and affiliations

  • Alisa G. Woods
    • 1
  • Costel C. Darie
    • 2
  1. 1.Chemistry and Biomolecular Science Biochemistry and Proteomics GroupClarkson UniversityPotsdamUSA
  2. 2.Chemistry and Biomolecular Science Biochemistry and Proteomics GroupClarkson UniversityPotsdamUSA

About the editors

 Dr. Costel C. Darie started his biomedical career as a nurse at the Murgeni Hospital, Romania. He received his BS and MS in biochemistry at the Alexandru Ioan Cuza University from Iasi, Romania, and performed research under Dr. Vlad Artenie. He continued his Ph.D. studies with Dr. Wolfgang Haehnel at the Albert-Ludwigs Universitaet, Freiburg, Germany, after which he worked in the labs of Drs. Paul M. Wassarman & Micsunica Platica (Mount Sinai School of Medicine) and Thomas A. Neubert (New York University Medical Center). He currently is an Assistant Professor of Chemistry and Biomolecular Science at Clarkson University, where he is the lead of the Biochemistry and Proteomics Group.

Dr. Alisa Woods received her BS in psychology from the State University of New York (SUNY) at Plattsburgh and her PhD in biology from the University of California, Irvine, with Dr. Christine Gall. She continued with post-doctoral training at the University of Freiburg, Germany, with Dr. Michael Frotscher and completed a Master's degree in Mental Health Counseling at the University of Massachusetts, Boston. She is currently a Research Assistant Professor of Chemistry and Biomolecular Science at Clarkson University, where she works in the Laboratory for Biochemistry and Proteomics. She is also a counselor and neuropsychology researcher at the Neuropsychology Clinic at SUNY Plattsburgh.

Bibliographic information

  • Book Title Advancements of Mass Spectrometry in Biomedical Research
  • Editors Alisa G. Woods
    Costel C. Darie
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science Chemistry and Material Science (R0)
  • Hardcover ISBN 978-3-319-06067-5
  • Softcover ISBN 978-3-319-37892-3
  • eBook ISBN 978-3-319-06068-2
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XVI, 600
  • Number of Illustrations 47 b/w illustrations, 126 illustrations in colour
  • Topics Mass Spectrometry
    Biomedicine, general
  • Buy this book on publisher's site
Industry Sectors
Chemical Manufacturing


“Intended for intermediate and experienced readers, this is recommended reading and a must-have laboratory resource for those already involved in proteomics research. Advancements of mass spectrometry in biomedical research describes essential principles of MS and proteomics. It also offers updated information on popular proteomics-based MS applications and newly developed techniques. … It is recommended as both a textbook and a great laboratory benchtop reference.” (Mitsutoshi Setou and Ikuko Yao, Analytical and Bioanalytical Chemistry, Vol. 407, 2015)