© 2014

Adhesive Interactions of Mussel Foot Proteins

  • Nominated as an outstanding thesis by University of California, Santa Barbara

  • Investigate basic surface interactions by mussels

  • Understand surface forces apparatus

  • Investigates adhesion for human medical issues


Part of the Springer Theses book series (Springer Theses)

About this book


Water and moisture undermine strong adhesion to polar surfaces. Marine mussels, however, achieve durable underwater adhesion using a suite of proteins that are peculiar in having high levels of 3, 4-dihydroxyphenylalanine (Dopa). Mussel adhesion has inspired numerous studies on developing the next generation of wet adhesives. This thesis presents recent progress in understanding the basic surface and intermolecular interactions employed by mussels to achieve strong and durable wet adhesion. The surface forces apparatus (SFA) and various other techniques were applied to measure the interactions between mussel foot protein-3 fast (Mfp-3 fast) and the model substrate, mica, as well as the interactions between various mussel adhesive proteins. The results in this thesis show that Dopa plays an essential role in mussel adhesion, and that mussels delicately control the interfacial redox environment to achieve strong and durable Dopa mediated adhesion. The interplay between Dopa and hydrophobic interactions is also evident in mussel adhesion.


Mfps Mica Mussel Foot Proteins Surface Forces Apparatus Surface Interactions

Authors and affiliations

  1. 1.California Institute of TechnologyPasadenaUSA

About the authors

Dr. Yu grew up in Hangzhou, a beautiful city in eastern China. He received his B.Sc. in Chemical Engineering from Tsinghua University, China and his PhD in Chemical Engineering from University of California, Santa Barbara. Dr. Yu fell in love with the great sunshine and beach of the University of California, Santa Barbara campus during his 5 years PhD where he worked in Professor Jacob Israelachvili’s group. Yu conducted and pioneered outstanding research in many important areas including the wet adhesion of marine mussel adhesive proteins. Yu’s work has been recognized by multiple international journals and online media sources including Nature, Chemical Biology, ABC Science and the Faculty of 100. Yu is currently a postdoctoral scholar in the Chemistry and Chemical Engineering Division at California Institute of Technology.

Bibliographic information

Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods