Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

  • Michael B. A. Oldstone
  • Hugh Rosen

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 378)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera, Edward Roberts
    Pages 1-21
  3. Michael A. Hanson, Robert Peach
    Pages 23-53
  4. Yuquan Xiong, Timothy Hla
    Pages 85-105
  5. Roland Martin, Mireia Sospedra
    Pages 149-170
  6. Mi Ra Chang, Hugh Rosen, Patrick R. Griffin
    Pages 171-182
  7. Back Matter
    Pages 183-184

About this book


This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of  signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis.  One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.


CNS inflammation Cytokine storm Endothelial integrity Influenza virus infection Multiple sclerosis S1P signaling system

Editors and affiliations

  • Michael B. A. Oldstone
    • 1
  • Hugh Rosen
    • 2
  1. 1.Department of Immunology and Microbial SciiencesThe Scripps Research InstituteLa JollaUSA
  2. 2.Department of Chemical PhysiologyThe Scripps Research InstituteLa JollaUSA

Bibliographic information

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