Current Advances in Osteosarcoma

  • Eugenie S. Kleinerman, M.D.

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 804)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Novel Therapeutic Targets

    1. Front Matter
      Pages 31-31
    2. Carol H. Lin, Tao Ji, Cheng-Fong Chen, Bang H. Hoang
      Pages 33-45
    3. Ashley N. Rettew, Patrick J. Getty, Edward M. Greenfield
      Pages 47-66
    4. Madonna M. McManus, Kurt R. Weiss, Dennis P. M. Hughes
      Pages 67-92
    5. Jared R. Mortus, Yi Zhang, Dennis P. M. Hughes
      Pages 93-118
    6. Lisa A. Kafchinski, Kevin B. Jones
      Pages 119-127
    7. Linchao Lu, Weidong Jin, Hao Liu, Lisa L. Wang
      Pages 129-145
    8. Janice Santiago O’Farrill, Nancy Gordon
      Pages 147-160
    9. Jonathan Gill, David Geller, Richard Gorlick
      Pages 161-177
  3. Tumor Microenvironment

    1. Front Matter
      Pages 179-179
    2. Ling Ren, Chand Khanna
      Pages 181-201
    3. Gangxiong Huang, Kazumasa Nishimoto, Yuanzheng Yang, Eugenie S. Kleinerman
      Pages 203-217
  4. Unique Osteosarcoma Models

    1. Front Matter
      Pages 219-219
    2. A. B. Mohseny, P. C. W. Hogendoorn
      Pages 221-236
  5. Novel Therapeutic Approaches Based on Biology: Tumor Targeted Therapy

    1. Front Matter
      Pages 257-257
    2. Pooja Hingorani, Valerie Sampson, Christina Lettieri, E. Anders Kolb
      Pages 259-283
  6. Novel Therapeutic Approaches Based on Biology: Immunotherapy

    1. Front Matter
      Pages 305-305
    2. Christopher DeRenzo, Stephen Gottschalk
      Pages 323-340
    3. Nidale Tarek, Dean A. Lee
      Pages 341-353
  7. Eugenie S. Kleinerman
    Pages E1-E1
  8. Back Matter
    Pages 355-359

About this book


Current Advances in Osteosarcoma summarizes  molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat.


In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will ​provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward.


bone cancer cancer metastasis osteosarcoma pediatric cancer

Editors and affiliations

  • Eugenie S. Kleinerman, M.D.
    • 1
  1. 1.Division of Pediatrics, Department of Cancer Biology, The Mary V. and John A. Reilly Distinguished ChairUniversity of Texas M.D. Anderson Cancer CenterHoustonUSA

Bibliographic information

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