Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra

  • Giuseppe Giovanni
  • Vincenzo Di Matteo
  • Ennio Esposito

Part of the Journal of Neural Transmission. Supplementa book series (NEURALTRANS, volume 73)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Birth of dopaminergic neurons

    1. Front Matter
      Pages 1-1
    2. R Orme, RA Fricker-Gates, MA Gates
      Pages 3-18
  3. SNc Dopaminergic neurons

    1. Front Matter
      Pages 20-20
    2. Tomás González-Hernández, Domingo Afonso-Oramas, Ignacio Cruz-Muros
      Pages 21-37
    3. L Prensa, J M Giménez-Amaya, A Parent, J Bernácer, C Cebrián
      Pages 49-58
    4. Christian R Lee, James M Tepper
      Pages 71-90
    5. Ezia Guatteo, Maria Letizia Cucchiaroni, Nicola B. Mercuri
      Pages 91-101
    6. Yoshiyuki Ishida, Tatsuya Kozaki, Yoshikazu Isomura, Sachiko Ito, Ken-ichi Isobe
      Pages 129-133
    7. Marcelo M. S. Lima, Angela B. B. Reksidler, Maria A. B. F. Vital
      Pages 135-145
    8. Claudio Da Cunha, Evellyn Claudia Wietzikoski, Mariza Bortolanza, Patricia Andréia Dombrowski, Lucélia Mendes dos Santos, Suelen Lúcio Boschen et al.
      Pages 147-160
    9. Catherine R. G. Jones, Marjan Jahanshahi
      Pages 161-171
    10. Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Gergely Orbán, Giuseppe Crescimanno, Ennio Esposito et al.
      Pages 173-182
  4. Death of SNc Dopaminergic neurons

    1. Front Matter
      Pages 184-184
    2. Nina Eriksen, Anette Kirstine Stark, Bente Pakkenberg
      Pages 203-213
    3. Olga Corti, Margot Fournier, Alexis Brice
      Pages 215-221
    4. Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo
      Pages 223-243
    5. Carlos Barcia, Francisco Ros, María Angeles Carrillo, David Aguado-Llera, Carmen María Ros, Aurora Gómez et al.
      Pages 245-252
    6. Carlos Barcia, Carmen M. Ros, María A. Carrillo, Francisco Ros, Aurora Gomez, Vicente de Pablos et al.
      Pages 253-258
    7. Angela B. Reksidler, Marcelo M. S. Lima, Patrícia A. Dombrowski, Gabriela F. Barnabé, Monica L. Andersen, Sergio Tufik et al.
      Pages 259-268
    8. Moisés García-Arencibia, Concepción García, Alexander Kurz, José A. Rodríguez-Navarro, Suzana Gispert-Sánchez, María A. Mena et al.
      Pages 269-275
  5. Saving the SNc Dopaminergic neurons

    1. Front Matter
      Pages 278-278
    2. Oscar Arias-Carrión, Elizabeth Yamada, Nils Freundlieb, Miriam Djufri, Lukas Maurer, Guido Hermanns et al.
      Pages 279-285
    3. K.-C. Sonntag, F. Simunovic, R. Sanchez-Pernaute
      Pages 287-299
    4. Takao Yasuhara, Isao Date
      Pages 301-309
    5. Daniela Besong Agbo, Frauke Neff, Florian Seitz, Christian Binder, Wolfgang H. Oertel, Michael Bacher et al.
      Pages 311-315
    6. Giuseppe Di Giovanni
      Pages 317-331
    7. Vincenzo di Matteo, Massimo Pierucci, Giuseppe Di Giovanni, Luana Katia Dragani, Stefania Murzilli, Andreina Poggi et al.
      Pages 333-341
  6. Back Matter
    Pages 343-369

About this book


This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and pathology of the substantia nigra pars compacta (SNc) dopaminergic neurons. The single chapters, written by top scientists in their fields, explore the life cycle of dopaminergic neurons from their birth to death, the cause of Parkinson's disease, the second most common and disabling condition in the elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is symptomatic rather than preventive. The mechanisms by which alterations cause neuronal death, new therapeutic approaches and the latest evidence of a possible de novo neurogenesis in the SNc are reviewed and singled out in different chapters. This book bridges basic science and clinical practice and will prepare the reader for the next few years, which will surely be eventful in terms of the progress of dopamine research.


Basal ganglia Cannabinoid Dopamine Neurobiology Parkinson Parkinson's disease SNc Substantia nigra pars compacta anatomy dopamine cell gene therapy neurons physiology

Editors and affiliations

  • Giuseppe Giovanni
    • 1
  • Vincenzo Di Matteo
    • 2
  • Ennio Esposito
    • 3
  1. 1.Fac. Medicina e ChirurgiaUniversità di PalermoPalermoItaly
  2. 2.Mario NegriIstituto di Ricerche FarmacologicheSanta Maria ImbaroItaly
  3. 3.Mario NegriIstituto di Ricerche FarmacologicheSanta Maria ImbaroItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Vienna 2009
  • Publisher Name Springer, Vienna
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-211-92659-8
  • Online ISBN 978-3-211-92660-4
  • Series Print ISSN 0303-6975
  • Buy this book on publisher's site
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