© 2000

Novel Cytokine Inhibitors

  • Gerry A. Higgs
  • Brian Henderson

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Mary Lee MacKichan, Anthony L. DeFranco
    Pages 9-42
  3. Rodger A. Allen, Stephen E. Rapecki
    Pages 43-82
  4. Peter I. Croucher, Ingunn Holen, Philip G. Hargreaves
    Pages 103-122
  5. Amanda Suitters, Roly Foulkes
    Pages 123-143
  6. Michael F. Smith Jr.
    Pages 177-199
  7. Christian Bogdan, Yoram Vodovotz, John Letterio
    Pages 217-242
  8. Back Matter
    Pages 263-270

About this book


Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors. Accordingly, experts were drawn from different backgrounds including academic research institutes, the pharmaceutical industry and clinical pharmacology. In each area, the opportunities for drug development are highlighted and, where possible, clinical data is reviewed.


cell clinic cytokine cytokines diseases enzyme enzymes immunity infection infectious disease microorganisms protein regulation rheumatism therapy

Editors and affiliations

  • Gerry A. Higgs
    • 1
  • Brian Henderson
    • 2
  1. 1.Celltech ChiroscienceSlough BerkshireUK
  2. 2.Cellular Microbiology Research Group Eastman Dental InstituteUniversity College LondonLondonUK

Bibliographic information

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