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Neuroinflammatory Mechanisms in Alzheimer’s Disease Basic and Clinical Research

  • Joseph Rogers

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Basic Research Overview

    1. Front Matter
      Pages 1-1
    2. Harry E. Peery, Ron W. Strohmeyer, Joseph Rogers
      Pages 3-49
  3. Clinical Research Overview

    1. Front Matter
      Pages 51-51
  4. Topics of Special Interest

    1. Front Matter
      Pages 65-65
    2. Robert Veerhuis, Freek L. Van Muiswinkel, C. Erik Hack, Piet Eikelenboom
      Pages 67-87
    3. Bonnie M. Bradt, Stephen A. O’Barr, Jack X. Yu, Neil R. Cooper
      Pages 89-103
    4. Douglas G. Walker, Lih-Fen Lue, Andis Klegeris, Patrick L. McGeer
      Pages 173-195
    5. Ian R. A. Mackenzie
      Pages 209-224
    6. Haruhiko Akiyama
      Pages 225-236
    7. Caleb E. Finch, Valter D. Longo
      Pages 237-256
  5. Back Matter
    Pages 257-264

About this book

Introduction

Research into inflammatory mechanisms that may cause damage to the Alzheimer's disease (AD) brain has now been ongoing for nearly two decades. Some two dozen clinical studies have strongly suggested that conventional anti-inflammatory drugs may be useful to delay the onset or slow the progression of the disorder. Moreover, virtually all the major systems of the innate immune response appear to be present, and most are upregulated, in pathologically-vulnerable regions of the AD brain. These new findings are described in this volume - first in overview form, followed by chapters on topics of special interest. In many ways, to understand AD brain inflammation, one need only review a text on peripheral inflammation biology, leaving out the chapters on humoral medi­ ators and substituting microglia for macrophages. In several other key respects, however, AD brain inflammation is unique, due primarily to idiosyncratic interac­ tions of inflammatory mediators and mechanisms with classical AD pathology: amyloid ~ peptide(A~) deposits and neurofibrillary tangles (NFTs). For this reason, some key concepts about the inflammation that occurs in AD may warrant discus­ sion in preparation for the more detailed chapters that follow.

Keywords

Alzheimer's disease Alzheimer´s disease biochemistry chemistry clinical research clinical trial cytokine cytokines drugs inflammation neurons physiology research treatment

Editors and affiliations

  • Joseph Rogers
    • 1
  1. 1.Sun Health Research InstituteSun CityUSA

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