© 2001

Tetracyclines in Biology, Chemistry and Medicine

  • Mark Nelson
  • Wolfgang Hillen
  • Robert A. Greenwald

Table of contents

  1. Front Matter
    Pages I-X
  2. Chemistry, biology and microbiologic action of tetracyclines

    1. Front Matter
      Pages 1-1
    2. Siegfried Schneider
      Pages 65-104
  3. Tetracycline-dependent gene regulation: A versatile tool for all organisms

  4. Use of tetracyclines as non-antimicrobial medicinal agents

    1. Front Matter
      Pages 197-197
    2. George J. Armelagos, Kristi Kolbacher, Kristy Collins, Jennifer Cook, Maria Krafeld-Daugherty
      Pages 219-236
    3. Roeland Hanemaaijer, Natascha van Lent, Timo Sorsa, Tuula Salo, YrjŐ, T. Konttinen et al.
      Pages 267-281
    4. Mukundan G. Attur, Mandar N. Dave, Nirupama Mohandas, Indravadan R. Patel, Steven B. Abramson, Ashok R. Amin
      Pages 295-310
    5. Helena Marzo-Ortega, Roland M Strauss, Paul Emery
      Pages 311-324
    6. Brad R. Zerler
      Pages 325-332
  5. Back Matter
    Pages 333-336

About this book


The tetracyclines have an illustrious history as therapeutic agents which dates back over half a century. Initially discovered as an antibiotic in 1947, the four­ ringed molecule has captured the fancy of chemists and biologists over the ensuing decades. Of further interest, as described in the chapter by George Armelagos, tetracyclines were already part of earlier cultures, 1500-1700 years ago, as revealed in traces of drug found in Sudanese Nubian mummies. The diversity of chapters which this book presents to the reader should illus­ trate the many disciplines which have examined and seen benefits from these fascinating natural molecules. From antibacterial to anti-inflammatory to anti­ autoimmunity to gene regulation, tetracyclines have been modified and redesigned for various novel properties. Some have called this molecule a biol­ ogist's dream because of its versatility, but others have seen it as a chemist's nightmare because of the synthetic chemistry challenges and "chameleon-like" properties (see the chapter by S. Schneider).


Antibiotika RNA antibiotics biology cancer chemistry diseases eukaryote gene expression genes infectious disease molecular mechanisms oncogene protein regulation

Editors and affiliations

  • Mark Nelson
    • 1
  • Wolfgang Hillen
    • 2
  • Robert A. Greenwald
    • 3
  1. 1.Paratek PharmaceuticalsBostonUSA
  2. 2.Lehrstuhl für MikrobiologieFriedrich-Alexander UniversitätErlangenGermany
  3. 3.Division of RheumatologyLong Island Jewish Medical CenterNew Hyde ParkUSA

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