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Mechanisms and Mediators of Neuropathic Pain

  • Annika B. Malmberg
  • Sandra R. Chaplan

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Peripheral consequences of nerve injury

    1. Front Matter
      Pages 1-1
    2. Joel A. Black, Theodore R. Cummins, Sulayman D. Dib-Hajj, Stephen G. Waxman
      Pages 23-50
    3. Valerie M. K. Verge, Tracy D. Wilson-Gerwing, Laurie A. Karchewski, Kelly A. Gratto
      Pages 51-65
  3. Spinal cord plasticity following peripheral nerve injury

    1. Front Matter
      Pages 77-77
    2. Victoria Chapman, Anthony H. Dickenson
      Pages 79-87
    3. Susan M. Carlton, Richard E. Coggeshall
      Pages 89-106
  4. Neuropathic pain: preclinical and clinical paradigms

    1. Front Matter
      Pages 107-107
    2. Jin Mo Chung, Kyungsoon Chung
      Pages 109-125
    3. Nigel A. Calcutt, Jason D. Freshwater
      Pages 127-152
    4. Karen M. Park, Richard H. Gracely
      Pages 175-197
  5. New treatment strategies for neuropathic pain

    1. Front Matter
      Pages 199-199
    2. Per Kristian Eide
      Pages 201-209
  6. Back Matter
    Pages 255-260

About this book

Introduction

Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences.
This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field.

Keywords

Nervous System adenosine behavior biology cell cytokine molecular biology neurochemistry neurology neurons pain physiology spinal cord tissue treatment

Editors and affiliations

  • Annika B. Malmberg
    • 1
  • Sandra R. Chaplan
    • 2
  1. 1.NeurogesX, Inc.San CarlosUSA
  2. 2.RW Johnson Pharmaceutical InstituteSan DiegoUSA

Bibliographic information

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