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© 2003

Modern Methods of Drug Discovery

  • Alexander Hillisch
  • Rolf Hilgenfeld
Book

Part of the EXS book series (EXS, volume 93)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Helmut Giersiefen, Rolf Hilgenfeld, Alexander Hillisch
    Pages 1-18
  3. Martin J. Page, Chris Moyses, Mary J. Cunningham, Gordon Holt, Alastair Matheson
    Pages 19-30
  4. David B. Jackson, Eric Minch, Robin E. Munro
    Pages 31-69
  5. Ralf Thiericke
    Pages 71-85
  6. Alexander Hillisch, Rolf Hilgenfeld
    Pages 157-181
  7. Martin Vogtherr, Klaus Fiebig
    Pages 183-202
  8. John H. van Drie, Douglas C. Rohrer, James R. Blinn, Hua Gao
    Pages 203-221
  9. Glen E. Kellogg, Simon F. Semus
    Pages 223-241
  10. Han van de Waterbeemd
    Pages 243-257
  11. Back Matter
    Pages 279-292

About this book

Introduction

This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the thirteen chapters reviews the theory, background and application of a key technology in drug discovery, complemented by an extensive list of references to the original literature.

This concise source of information will be useful for researchers, both in industry and academia, as well as students in the fields of medicinal, pharmaceutical and computational chemistry, bioinformatics, biochemistry, molecular biology and pharmacology.

Features and benefits

- Structure-based drug design, molecular modeling, bioinformatics, screening methods, combinatorial chemistry and physicochemical concepts in drug discovery are comprehensively covered.

- The volume is written from the viewpoint of the "drug researcher" working in the pharmaceutical industry, and also presents chapters on novel approaches developed in academia.

- Offers high practical value for young scientists who need a quick introduction to the topic.

- Provides an overview of the drug discovery process, particularly for specialized scientists working in drug discovery and pharma-managers.

Keywords

Proteomics biochemistry bioinformatics biology chemistry drug drug design drug development drug discovery metabolism molecular biology pharmaceutical pharmacology protein research

Editors and affiliations

  • Alexander Hillisch
    • 1
  • Rolf Hilgenfeld
    • 2
  1. 1.Structural Bioinformatics and Drug DesignEnTec GmbHJenaGermany
  2. 2.Institut für Molekulare Biotechnologie e.V.Abt. Strukturbiologie-KristallographieJenaGermany

Bibliographic information

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