Toward a Molecular Basis of Alcohol Use and Abuse

  • B. Jansson
  • H. Jörnvall
  • U. Rydberg
  • L. Terenius
  • B. L. Vallee

Part of the Experientia book series (EXS, volume 71)

Table of contents

  1. Front Matter
    Pages I-X
  2. Perspectives

    1. Bert L. Vallee
      Pages 1-8
  3. Neuropharmacological aspects

    1. C. Alling, L. Gustavsson, C. Larsson, C. Lundqvist, D. Rodriguez, P. Simonsson
      Pages 19-28
    2. R. Roivainen, B. Hundle, R. O. Messing
      Pages 29-38
    3. Stefano Biffo, Georg Dechant, Hitoshi Okazawa, Yves-Alain Barde
      Pages 39-48
    4. Norbert Wilke, Michael Sganga, Steven Barhite, Michael F. Miles
      Pages 49-59
    5. Paula L. Hoffman, Boris Tabakoff
      Pages 61-70
    6. S. Nakanishi, M. Masu, Y. Bessho, Y. Nakajima, Y. Hayashi, R. Shigemoto
      Pages 71-80
    7. J.-C. Schwartz, J. Diaz, N. Griffon, D. Levesque, M.-P. Martres, P. Sokoloff
      Pages 81-92
    8. Paul R. Hartig
      Pages 93-102
    9. G. F. Koob, S. Rassnick, S. Heinrichs, F. Weiss
      Pages 103-114
  4. Biological markers and special clinical features

    1. George R. Uhl
      Pages 133-141
    2. Lars Farde, Stefan Pauli, Jan-Eric Litton, Christer Halldin, Jack Neiman, Göran Sedvall
      Pages 143-153
    3. Markku Linnoila, Matti Virkkunen, Theodore George, Michael Eckardt, James D. Higley, David Nielsen et al.
      Pages 155-163
    4. J. M. van Ree, M. Kornet, C. Goosen
      Pages 165-174
    5. M. Salaspuro
      Pages 185-195
    6. M. Ingelman-Sundberg, I. Johansson, I. Persson, M. Oscarson, Y. Hu, L. Bertilsson et al.
      Pages 197-207
  5. Enzymatic aspects

    1. Hans Jörnvall
      Pages 221-229
    2. Joram Piatigorsky, Marc Kantorow, Rashmi Gopal-Srivastava, Stanislav I. Tomarev
      Pages 241-250
    3. M. Ghosh, A. Avezoux, C. Anthony, K. Harlos, C. C. F. Blake
      Pages 251-260
    4. Hans Eklund, S. Ramaswamy, Bryce V. Plapp, Mustafa El-Ahmad, Olle Danielsson, Jan-Olov Höög et al.
      Pages 269-277
    5. David I. N. Sherman, Roberta J. Ward, Akira Yoshida, Timothy J. Peters
      Pages 291-300
    6. Bryce V. Plapp
      Pages 311-322
  6. Clinical aspects and pharmacological approaches

    1. Bengt Jansson
      Pages 333-340
    2. Marc A. Schuckit
      Pages 341-348
    3. Charles P. O’Brien
      Pages 349-359
    4. Roscoe O. Brady
      Pages 383-393
    5. Enoch Gordis
      Pages 395-404
  7. Back Matter
    Pages 405-409

About this book


The 39 chapters in this volume consider subjects ranging from genetics, markers, and molecular biology of alcoholism, to clinical observations and treatment. The aim is to integrate pertinent information from the fields of molecular and cell biology with view to establishing a molecular basis of alcohol use and abuse. An initial preview summarizes historical aspects of alcohol use, and subsequent chapters concern novel drugs, pharmacological aspects, gene structures, cloning, and enzymatic properties. Also contributions by "non-traditional" alcohol scientists have been included in this collection, in order to highlight possible interaction and parallels between different fields. Novel results of particular interest include up-dated summaries on receptors, enzymes, and other proteins, as well as corresponding gene structures and regulation, setting the basis for distinguishing markers and pinpointing further possible pharmacological treatments.


Glutamat Termination behavior cell biology cytochrome P450 enzymes gene expression genetics metabolism molecular biology molecular control proteins regulation signal transduction tissue

Editors and affiliations

  • B. Jansson
    • 1
  • H. Jörnvall
    • 2
  • U. Rydberg
    • 3
  • L. Terenius
    • 3
  • B. L. Vallee
    • 4
  1. 1.Department of Psychiatry, Karolinska InstitutetHuddinge University HospitalHuddingeSweden
  2. 2.Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden
  3. 3.Department of Clinical NeuroscienceKarolinska InstitutetStockholmSweden
  4. 4.Center for Biochemical and Biophysical Sciences and MedicineHarvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Birkhäuser Basel 1994
  • Publisher Name Birkhäuser Basel
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-0348-7332-1
  • Online ISBN 978-3-0348-7330-7
  • Series Print ISSN 1023-294X
  • Buy this book on publisher's site
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