Methods in Protein Sequence Analysis

  • Hans Jörnvall
  • Jan-Olov Höög
  • Ann-Margreth Gustavsson

Part of the Advances in Life Sciences book series (ALS)

Table of contents

  1. Front Matter
    Pages I-8
  2. Sequencer Methodology and Instrumentation

    1. Brigitte Wittmann-Liebold, Lothar Matschull, Ulrike Pilling, Hans-Arthur Bradaczek, Horst Graffunder
      Pages 9-21
    2. Adam S. Inglis, Robert L. Moritz, Geoffrey S. Begg, Gavin E. Reid, Richard J. Simpson, Horst Graffunder et al.
      Pages 23-34
    3. David H. Hawke, Victoria L. Boyd
      Pages 35-45
    4. Richard A. Laursen, Thomas T. Lee, James D. Dixon, Song-Ping Liang
      Pages 47-54
  3. Sample Preparation and Analysis

    1. Richard J. Simpson, Robert L. Moritz, Gavin E. Reid, Larry D. Ward
      Pages 67-77
    2. John E. Shively
      Pages 91-101
    3. H. H. Rasmussen, J. Van Damme, G. Bauw, M. Puype, B. Gesser, J. E. Celis et al.
      Pages 103-114
    4. Ronald L. Niece, Lowell H. Ericsson, Audree V. Fowler, Alan J. Smith, David W. Speicher, John W. Crabb et al.
      Pages 133-141
    5. L. H. Ericsson, D. Atherton, R. Kutny, A. J. Smith, J. W. Crabb
      Pages 143-150
  4. Modified Residues, Chemical Problems and Synthetic Peptides

    1. H. Ponstingl, L. D. Barnes, C. Granzow, R. H. Himes, G. Maier, G. Nasioulas
      Pages 169-176
    2. E. Appella, J. G. Omichinski, G. M. Clore, A. M. Gronenborn, K. Sakaguchi
      Pages 187-195
    3. Jan Johansson, Tore Curstedt, Per Persson, Bengt Robertson, Björn Löwenadler, Hans Jörnvall
      Pages 197-204
  5. Proteolysis

    1. R. S. Fuller, C. Brenner, P. Gluschankof, C. A. Wilcox
      Pages 205-214
    2. Alexander Wlodawer, Maria Miller, Amy L. Swain, Mariusz Jaskólski
      Pages 215-221
    3. Gunnar von Heijne
      Pages 231-238
    4. H. Mattras, L. Chiche, M. Bianchi, R.-A. Boigegrain, B. Castro, M.-A. Coletti-Previero
      Pages 239-248
  6. Mass Spectrometry

    1. Thomas Covey, Bori Shushan, Ron Bonner, Werner Schröder, Ferdinand Hucho
      Pages 249-256
    2. D. F. Hunt, J. Shabanowitz, M. A. Moseley, A. L. McCormack, H. Michel, P. A. Martino et al.
      Pages 257-266
    3. A. G. Craig, Å. Engström, G. Lindeberg, H. Bennich, M. Serwe, E. Hoffmann-Posorske et al.
      Pages 275-284
  7. Synergism with DNA Analysis

    1. J. Carlstedt-Duke, P.-E. Strömstedt, K. Dahlman-Wright, T. Härd, J. Zilliacus, C. Cairns et al.
      Pages 293-300
    2. S. Magnusson, S. C. Bock, K. Skriver
      Pages 301-311
    3. Stefan Ståhl, Per-Åke Nygren, Mathias Uhlén
      Pages 313-320
  8. Predictions, Data Banks, Patterns and Tertiary Structures

    1. Bert L. Vallee, David S. Auld
      Pages 363-372
    2. Tom Blundell, Jon Cooper, Dan Donnelly, Huub Driessen, Yvonne Edwards, Frank Eisenmenger et al.
      Pages 373-385
  9. Back Matter
    Pages 397-398

About this book


Methods in protein sequence analysis constitute important fields in rapid progress. We have experienced a continuous increase in analytical sensitivity coupled with decreases in time necessary for purification and analysis. Several generations of sequencers, liquid/solid/gas-phase, have passed by and returned in other shapes during just over two decades. Similarly, the introduction of HPLC permitted an enormous leap forward in this as in other fields of biochemistry, and we now start to see new major advances in purification/analysis through capillary electrophoresis. Furthermore, progress in the field of mass spectrometry has matched that in chemical analysis and we witness continuous development, now emphasizing ion spray and other mass spectrometric approaches. In short, protein analysis has progressed in line with other developments in modern science and constitutes an indispensable, integral part of present-day molecular biology. Even the available molecular tools, in the form of proteases with different specificities, have increased in number, although we still have far to go to reach an array of "restriction proteases" like the sets of nucleases available to the molecular geneticist. Of course, conferences have been devoted to protein sequence analysis, in particular the MPSA (Methods in Protein Sequence Analysis) series, of which the 8th conference took place in Kiruna, Sweden, July 1-6 1990. Again, we witnessed much progress, saw new instruments, and experienced further interpretational insights into protein mechanisms and functions.


membrane proteins protein protein sequence Secondary structure tertiary structure

Editors and affiliations

  • Hans Jörnvall
    • 1
  • Jan-Olov Höög
    • 1
  • Ann-Margreth Gustavsson
    • 1
  1. 1.Department of Chemistry IKarolinska InstituteStockholmSweden

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