Table of contents

  1. Front Matter
    Pages i-vi
  2. Christine Louis-Dit-Sully, Britta Blumenthal, Marlena Duchniewicz, Katharina Beck-Garcia, Gina J. Fiala, Esmeralda Beck-García et al.
    Pages 9-23
  3. Christine Louis-Dit-Sully, Wolfgang W. A. Schamel
    Pages 25-39
  4. Hans Ulrich Weltzien, Stefan F. Martin, Jean-François Nicolas
    Pages 41-49
  5. Peter S. Friedmann, Christopher Pickard
    Pages 51-71
  6. Stefan F. Martin, Sonja S. Schmucker, Anne Richter
    Pages 73-88
  7. Marc Vocanson, Amine Achachi, Virginie Mutez, Magalie Cluzel-Tailhardat, Béatrice Le Varlet, Aurore Rozières et al.
    Pages 89-100
  8. Philipp R. Esser, Ian Kimber, Stefan F. Martin
    Pages 101-114
  9. C. J. Earnshaw, T. Pecaric-Petkovic, B. K. Park, D. J. Naisbitt
    Pages 137-163
  10. Maria J. Torres, Cristobalina Mayorga, Natalia Blanca-López, Miguel Blanca
    Pages 165-184

About this book

Introduction

This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods.

The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.

Keywords

Contact allergen Hypersensitivity T cell assay

Editors and affiliations

  • Stefan F. Martin
    • 1
  1. 1.Department of Dermatology and VenereologyUniversity Medical Center FreiburgFreiburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-0348-0726-5
  • Copyright Information Springer Basel 2014
  • Publisher Name Springer, Basel
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-0348-0725-8
  • Online ISBN 978-3-0348-0726-5
  • Series Print ISSN 1023-294X
  • About this book
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