The First Once-daily Long-acting Beta2 Agonist for COPD

  • Alexandre Trifilieff

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages i-vii
  2. James F. Donohue, Matthew C. Miles, Jill A. Ohar
    Pages 1-23
  3. Alexandre Trifilieff, Steven J. Charlton, Robin A. Fairhurst
    Pages 25-37
  4. Robin A. Fairhurst, Steven J. Charlton, Alexandre Trifilieff
    Pages 39-65
  5. Jutta Beier, Kai M. Beeh
    Pages 67-76
  6. David Lawrence, Frank Bretz, Stuart Pocock
    Pages 77-92
  7. David Young, Lee Wood, Dilraj Singh, Juergen Dederichs
    Pages 117-128

About this book


Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available.

This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled β2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.


Asthma Beta-2-Agonists Bronchitis Bronchodilatator Lung function

Editors and affiliations

  • Alexandre Trifilieff
    • 1
  1. 1.Respiratory Diseases AreaNovartis Institutes for BioMedical ReseachBaselSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer Basel 2014
  • Publisher Name Springer, Basel
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-0348-0708-1
  • Online ISBN 978-3-0348-0709-8
  • Series Print ISSN 2296-6056
  • Series Online ISSN 2296-6064
  • Buy this book on publisher's site
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