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Genomics of Pattern Recognition Receptors

Applications in Oncology and Cardiovascular Diseases

  • Anton G. Kutikhin
  • Arseniy E. Yuzhalin
Book

Table of contents

  1. Front Matter
    Pages i-xi
    PDF
  2. The Biology of Toll-Like Receptors and NOD-Like Receptors: The Toggles of Inflammation
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 1-25
  3. Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 27-32
  4. Structural Genomic Variation in TLR4 Gene and Cancer
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 33-55
  5. Structural Genomic Variation in Other Toll-Like Receptors and Cancer
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 57-76
  6. Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 77-100
  7. Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 101-121
  8. Structural Genomic Variation in NOD-Like Receptors and Cancer
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 123-151
  9. Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 153-167
  10. Hot Spots in the Field: Where Should We Go?
    Anton G. Kutikhin, Arseniy E. Yuzhalin
    Pages 169-176
  11. Back Matter
    Pages 177-185
    PDF

About this book

Introduction

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

Keywords

Cancer Cardiovascular diseases Immune response NOD-like receptors Pathogen-associated patterns Toll-like receptors

Authors and affiliations

  • Anton G. Kutikhin
    • 1
  • Arseniy E. Yuzhalin
    • 2
  1. 1.EpidemiologyKemerovo State Medical AcademyKemerovoRussia
  2. 2.Res Inst Cardiovascular DiseasesRussian Academy of Medical Sciences Siberian BranchKemerovoRussia

Bibliographic information

Industry Sectors
Pharma
Biotechnology