Antimicrobial Peptides and Innate Immunity

  • Pieter S. Hiemstra
  • Sebastian A. J. Zaat

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. H. U. Stotz, F. Waller, K. Wang
    Pages 29-51
  3. Aline Dias Paiva, Eefjan Breukink
    Pages 53-95
  4. Paula E. Beaumont, Hsin-Ni Li, Donald J. Davidson
    Pages 97-121
  5. Mona Ståhle
    Pages 123-139
  6. Thomas S. Wilkinson, Ali Roghanian, Jean-Michel Sallenave
    Pages 141-166
  7. Wim van ’t Hof, Menno J. Oudhoff, Enno C. I. Veerman
    Pages 167-181
  8. Mauricio Arias, Sebastian A. J. Zaat, Hans J. Vogel
    Pages 183-218
  9. Maira Goytia, Justin L. Kandler, William M. Shafer
    Pages 219-254
  10. Simon Jäger, Eduard F. Stange, Jan Wehkamp
    Pages 255-273
  11. Jennifer A. Bartlett, Paul B. McCray Jr.
    Pages 275-306
  12. Gimano D. Amatngalim, Pieter S. Hiemstra
    Pages 307-320
  13. Nicole J. Afacan, Laure M. Janot, Robert E. W. Hancock
    Pages 321-358
  14. Birgitta Agerberth, Peter Bergman, Gudmundur H. Gudmundsson
    Pages 359-375
  15. Back Matter
    Pages 377-384

About this book


Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. This book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic.

The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair.  Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.


Antimicrobial peptides Endogenous antibiotics Host defense peptides Host-microbe interaction during infection Inflammatory and infectious diseases Innate immunity

Editors and affiliations

  • Pieter S. Hiemstra
    • 1
  • Sebastian A. J. Zaat
    • 2
  1. 1., Department of PulmonologyLeiden University Medical CenterLeidenNetherlands
  2. 2.Ctr for Infection & Immun. Amsterdam, Dept. Medical MicrobiologyUniversity of AmsterdamAmsterdamNetherlands

Bibliographic information

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