IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

  • Valérie Quesniaux
  • Bernhard Ryffel
  • Franco Padova

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Discovery and Basic Aspects of IL-17

    1. Front Matter
      Pages 1-1
    2. Franco Di Padova, Bernhard Ryffel, Valerie Quesniaux
      Pages 3-10
    3. Robert Sabat, Ellen Witte, Katrin Witte, Kerstin Wolk
      Pages 11-35
    4. Franco Di Padova, Bernhard Ryffel, Valerie Quesniaux
      Pages 71-89
    5. Marie-Laure Michel, Maria C. Leite-de-Moraes
      Pages 109-120
    6. Daniel Mucida, Hilde Cheroutre
      Pages 121-128
  3. Experimental Models of Disease

    1. Front Matter
      Pages 129-129
    2. Marije I. Koenders, Wim B. van den Berg
      Pages 131-141
    3. Bruno Schnyder, Silvia Schnyder-Candrian
      Pages 143-155
    4. Isabelle Couillin, Dieudonnée Togbe, Mamdouh Sedhom, Marc Le Bert, Hana Čipčić Paljetak, Francois Erard et al.
      Pages 157-164
    5. Louis-Marie Charbonnier, Benoit Vokaer, Philippe Lemaître, Alain Le Moine
      Pages 177-185
  4. Role of IL-23-1 L-17 in Infection and Tumor Control

    1. Front Matter
      Pages 187-187
    2. Andrea M. Cooper
      Pages 189-205
    3. Shabaana A. Khader, Jay K. Kolls
      Pages 207-218
    4. Frédérique Végran, Hélène Berger, Lionel Apetoh
      Pages 219-230
  5. IL-17 in Clinical Autoimmune Disease

    1. Front Matter
      Pages 231-231
    2. Aaron J. Martin, Stephen D. Miller
      Pages 243-257
    3. Isabelle Wolowczuk, Benjamin Pariente, Matthieu Allez, Mathias Chamaillard
      Pages 273-285
    4. Robert Sabat, Kerstin Wolk
      Pages 287-304
    5. Jean-Claude Lecron, Isabelle Paris, François-Xavier Bernard, Franck Morel
      Pages 305-317
  6. Novel Tools and Therapeutic Avenues

    1. Front Matter
      Pages 319-319
    2. Andrew L. Croxford, Thorsten Buch
      Pages 321-331
    3. Franco Di Padova, Jose Carballido
      Pages 333-347
  7. Back Matter
    Pages 349-354

About this book


The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.


Autoimmune diseases IL-17 and IL-22 cytokines IL-17 antibody neutralization Infection and tumor control Inflammatory diseases Th17 cells

Editors and affiliations

  • Valérie Quesniaux
    • 1
  • Bernhard Ryffel
    • 2
  • Franco Padova
    • 3
  1. 1.Institut de Transgénose, Labo. d'Immunologie etCNRSOrleans CX 2France
  2. 2.Institut de Transgénose, Labo. d'Immunologie etCNRSOrleans CX 2France
  3. 3.Novartis Institute for Biomedical, Research (NIBR)Novartis Pharma AGBaselSwitzerland

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