Proteases and Their Receptors in Inflammation

  • Nathalie Vergnolle
  • Michel Chignard

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Morley D. Hollenberg, Kristina K. Hansen, Koichiro Mihara, Rithwik Ramachandran
    Pages 1-25
  3. Bénédicte Manoury, Ali Roghanian, Jean-Michel Sallenave
    Pages 27-50
  4. Magali Pederzoli-Ribeil, Julie Gabillet, Véronique Witko-Sarsat
    Pages 73-100
  5. Vincent Lagente, Tatiana Victoni, Elisabeth Boichot
    Pages 101-122
  6. Giuseppe Lungarella, Eleonora Cavarra, Silvia Fineschi, Monica Lucattelli
    Pages 123-144
  7. Melissa Heightman, Tatiana Ort, Lawrence de Garavilla, Ken Kilgore, Geoffrey J. Laurent
    Pages 145-172
  8. Jean-Paul Motta, Laurence Martin, Nathalie Vergnolle
    Pages 173-215
  9. Fiona A. Russell, Jason J. McDougall
    Pages 217-242
  10. Giuseppe Cirino, Mariarosaria Bucci
    Pages 243-251
  11. Nicolas Cenac
    Pages 253-274
  12. Takahisa Imamura, Jan Potempa
    Pages 275-290
  13. Kathryn A. DeFea
    Pages 291-303
  14. Back Matter
    Pages 305-308

About this book


Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest.  In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response.

This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).


Infectious Diseases Inflammation Proteases Signalling

Editors and affiliations

  • Nathalie Vergnolle
    • 1
  • Michel Chignard
    • 2
  1. 1.CHU PurpanINSERM U 563Toulouse CedexFrance
  2. 2.Institut Pasteur, Unite de Defense Innee et InflammationINSERM U 874Paris Cedex 15France

Bibliographic information

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