© 2011

Replicating Vaccines

A New Generation

  • Philip R. Dormitzer
  • Christian W. Mandl
  • Rino Rappuoli

Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Today’s Live Attenuated Vaccines

    1. Front Matter
      Pages 1-1
    2. Gordon Dougan, David Goulding, Lindsay J. Hall
      Pages 3-14
    3. Thomas
      Pages 47-69
  3. Genetically Attenuated Micro-Organisms as Vaccines

    1. Front Matter
      Pages 71-71
    2. Luis Enjuanes, Jose L. Nieto-Torres, Jose M. Jimenez-Guardeño, Marta L. DeDiego
      Pages 73-97
    3. Yves Germani, Philippe J. Sansonetti
      Pages 99-117
    4. Michael V. Tullius, Marcus A. Horwitz
      Pages 119-169
  4. Manipulating Host-Pathogen Interactions to Make Vaccines

  5. New Types of Replicating Vaccines

    1. Front Matter
      Pages 283-283
    2. Justin A. Roby, Roy A. Hall, Alexander A. Khromykh
      Pages 299-320
    3. Scott J. Balsitis, Clayton W. Beard, Peter W. Mason
      Pages 331-347

About this book


Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

Editors and affiliations

  • Philip R. Dormitzer
    • 1
  • Christian W. Mandl
    • 2
  • Rino Rappuoli
    • 3
  1. 1.Novartis Vaccines & DiagnosticsCambridgeUSA
  2. 2.Novartis Vaccines & Diagnostics, Inc.CambridgeUSA
  3. 3.Novartis Vaccines & Diagnostics S.r.l.SienaItaly

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods


From the reviews:

“This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. … Given the renaissance in vaccinology this is a timely volume which … makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field.” (Paul Duprex, Microbiology Today, November, 2011)