© 2020

Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology

Overview of the First Eukaryome Congress at Institut Pasteur. Paris, October 16–18, 2019.

  • Nancy Guillen
Conference proceedings

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Anastasios D. Tsaousis, Emma L. Betts, Abby McCain, Jamie M. Newton, Vasana Jinatham, Eleni Gentekaki
    Pages 61-74
  3. P. Morán-Silva, M. E. Nieves-Ramírez, L. Rojas-Velázquez, A. Serrano-Vázquez, E. González-Rivas, E. Hernández-Hernández et al.
    Pages 75-86
  4. Carol A. Gilchrist
    Pages 87-96
  5. Eric Yixiao Cao, Arthur Mortha
    Pages 133-145
  6. Alfonso Olivos-García, Emma Saavedra, Sergio Enríquez-Flores, Nancy Guillen, Mario Nequiz-Avendaño, Yoalli Martínez et al.
    Pages 159-169
  7. César Díaz-Godínez, Arony Martínez-Flores, Raúl Argüello-García, Alfonso Olivos-García, Mario Néquiz-Avendaño, Julio César Carrero
    Pages 171-192
  8. Koushik Das, Tomoyoshi Nozaki
    Pages 193-212
  9. Silvia Castellanos-Castro, Arturo Aguilar-Rojas, Mariette Matondo, Quentin Gian Gianetto, Hugo Varet, Odile Sismeiro et al.
    Pages 225-238
  10. Kumiko Nakada-Tsukui, Tomoyoshi Nozaki
    Pages 239-249
  11. Megha Jain, Aashutosh Tripathi, Merlyn Emmanuel, Kuldeep Verma, Sunando Datta
    Pages 263-273

About these proceedings


The intestine is home to diverse bacterial communities forming the microbiome that influences host nutrition, immune functions and health. DNA-based methods have been instrumental to gain insight into the microbial eukaryotic diversity of the human gut. For instance, the microbiome share the intestinal ecosystem with a population of uni- and multi-cellular eukaryotic organisms. These eukaryotic organisms are very common and often very abundant in individuals with intestinal healthy conditions as well as those with intestinal diseases. The impact of the relationship between bacterial and eukaryotic organisms within the intestinal ecosystem on homeostasis and intestinal diseases is limited and can be considered an important emerging field of research. In addition, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. All these organisms and their interplay with bacteria and the human immune system are a challenge to assess the impact (present and future) of intestinal infectious diseases on public health.

This book presents an overview of the science presented and discussed in the First Eukaryome Congress, held from October 16th to 18th, 2019 at Pasteur Institute in Paris, France. This contributed volume is of special interest for PhD students, postdoctoral fellows, researchers and clinicians interested in the effect of the eukaryotic microbiome on human health.


Microbiome parasite-host interactions eukaryotic microbes mucosal immune homeostasis human intestine Immuno-modulation 3D tissue models Drug discovery Evolution Pathogenicity

Editors and affiliations

  1. 1.Institute PasteurParisFrance

About the editors

Dr. Nancy Guillen received her degree in Biology in 1972 at the Universidad Central de Venezuela in Caracas and her Doctorat d'Etat in Natural Sciences with speciality in Microbiology at the University of Paris Sud-Orsay (France) in 1979. She obtained her habilitation diploma at the same University in 1986 and got a permanent position as senior researcher at the National Centre for Research (CNRS-France) in 1982, she was a visiting fellow at Rockefeller University (1979) and at the Public Health Research Institute, New York City (1986-1987). Currently, Dr Nancy Guillén is Emeritus Research Director at the CNRS, a position she has held since 2015. Currently she is interested in understand the cellular and molecular mechanisms responsible for the invasion of tissue by the parasitic amoeba Entamoeba histolytica, the agent aetiology of amoebiasis. This infectious disease is endemic world wide. Dr Nancy Guillén has been consecutively vice-president of the scientific council of Pasteur Institute (until 2011), member of the scientific council in the department-INRA Animal Health (2006-2016), scientific coordinator of the Pasteur-Weizmann Council (2008-2013) and co-director of the department of Cell Biology and Infection, Institut Pasteur until 2014. Responsible for the cell biology section at the French National Laboratory of Excellence supporting Parasitology (Labex ParaFrap) and lead the Post-Doctoral Program in this Labex until end of 2019. Her research activity is documented by more than 182 publications in international peer-reviewed journals

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods