© 2020

Tumor Microenvironment

State of the Science

  • Alexander Birbrair


  • Provides a comprehensive overview of the various components that make up the tumor microenvironment

  • Explores the effects different viruses, such as hepatitis virus and HIV, have on the tumor microenvironment

  • Discusses the ways in which the cellular composition of the microenvironment promote and/or limit tumor progression


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1263)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Francesca Montenegro, Stefano Indraccolo
    Pages 1-11
  3. Hai Huang, Hongji Zhang, Amblessed E. Onuma, Allan Tsung
    Pages 13-23
  4. Eleonora Timperi, Vincenzo Barnaba
    Pages 25-43
  5. Dima Dandachi, Fanny Morón
    Pages 45-54
  6. Weiguo Han, Shereen A. Allam, Sherine F. Elsawa
    Pages 55-65
  7. David Roife, Bhaswati Sarcar, Jason B. Fleming
    Pages 67-84
  8. Ugo Testa, Elvira Pelosi, Germana Castelli
    Pages 85-115
  9. Rosemary Habib, Adnan Nagrial, Kenneth Micklethwaite, Kavitha Gowrishankar
    Pages 117-143
  10. Back Matter
    Pages 203-208

About this book


Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more.

Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.


Cancer Tumor Microenvironment Niche Signaling Cancer Stem Cells Cells Neoplasia Metastasis Invasion Migration Cancer Progression

Editors and affiliations

  • Alexander Birbrair
    • 1
  1. 1.Department of Radiology, Columbia University Medical Center, New York, NY, USADepartment of Pathology, Federal University of Minas GeraisBelo HorizonteBrazil

About the editors

Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA).

Bibliographic information

  • Book Title Tumor Microenvironment
  • Book Subtitle State of the Science
  • Editors Alexander Birbrair
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-44517-1
  • Softcover ISBN 978-3-030-44520-1
  • eBook ISBN 978-3-030-44518-8
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIII, 208
  • Number of Illustrations 2 b/w illustrations, 26 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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