Tissue-Specific Cell Signaling

  • Joana Vieira Silva
  • Maria João Freitas
  • Margarida Fardilha

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Cátia D. Pereira, Filipa Martins, Fernanda Marques, João Carlos Sousa, Sandra Rebelo
    Pages 1-32
  3. Sofia S. Pereira, Carolina B. Lobato, Mariana P. Monteiro
    Pages 33-61
  4. Sofia S. Pereira, Carolina B. Lobato, Mariana P. Monteiro
    Pages 63-91 Open Access
  5. Bruno M. Neves, Catarina R. Almeida
    Pages 93-131
  6. Alexandre M. Carmo, Sónia N. Henriques
    Pages 133-161
  7. Juliana Felgueiras, Vânia Camilo, Margarida Fardilha, Carmen Jerónimo
    Pages 195-223
  8. Joana Santiago, Daniela Patrício, Joana Vieira Silva
    Pages 225-255
  9. Maria João Freitas, Daniela Patrício, Margarida Fardilha
    Pages 257-277
  10. Fátima L. Monteiro, Inês Direito, Luisa A. Helguero
    Pages 279-315
  11. Bruno Marques, Ricardo Matos, Rui Gonçalo Martinho
    Pages 317-335
  12. Fábio Trindade, Inês Falcão-Pires, Andreas Kavazis, Adelino Leite-Moreira, Daniel Moreira-Gonçalves, Rita Nogueira-Ferreira
    Pages 337-368
  13. Henrique Araújo-Silva, Jorge Correia-Pinto, Rute S. Moura
    Pages 369-381
  14. Alexandra Moreira-Pais, Francisco Amado, Rui Vitorino, Hans-Joachim Appell Coriolano, José Alberto Duarte, Rita Ferreira
    Pages 383-408
  15. David F. Carrageta, Pedro F. Oliveira, Mariana P. Monteiro, Marco G. Alves
    Pages 409-436 Open Access

About this book


Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters.

This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors.

Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via


cell signaling signal transduction signal specificity tissue regulation proteome tissue specificity

Editors and affiliations

  • Joana Vieira Silva
    • 1
  • Maria João Freitas
    • 2
  • Margarida Fardilha
    • 3
  1. 1.Laboratory of Signal Transduction, Department of Medical SciencesInstitute of Biomedicine—iBiMED, University of AveiroAveiroPortugal
  2. 2.Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of MedicineKU LeuvenLeuvenBelgium
  3. 3.Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine—iBiMEDUniversity of AveiroAveiroPortugal

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