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© 2020

The Nitrile Imine 1,3-Dipole

Properties, Reactivity and Applications

  • Provides a comprehensive overview of nitrilimine chemistry from discovery to the present day

  • Is accessible to academic researchers, industry professionals and students

  • Highlights the diverse applications of nitrilimines

Book

Table of contents

  1. Front Matter
    Pages i-xi
  2. Craig Jamieson, Keith Livingstone
    Pages 1-12
  3. Craig Jamieson, Keith Livingstone
    Pages 13-35
  4. Craig Jamieson, Keith Livingstone
    Pages 37-97
  5. Craig Jamieson, Keith Livingstone
    Pages 99-150
  6. Craig Jamieson, Keith Livingstone
    Pages 151-152

About this book

Introduction

This book provides a comprehensive overview of the nitrilimine 1,3-dipole, from its initial discovery in 1959 to the most recent publications. Covering topics such as the core properties of the dipole and the various methods of synthesis available, it particularly highlights the diverse reactivity profile of the nitrilimine and its numerous applications in bioorthogonal and materials chemistry. The book is of interest to academic and industrial researchers working in this area and to those new to the field.

Keywords

Nitrile Imines 1,3-Dipolar Cycloaddition Nitrilium Betaine 1,3-Dipoles 2,5-Tetrazoles Bioorthogonal Chemistry Photolysis Protein Structure

Authors and affiliations

  1. 1.Department of Pure and Applied ChemistryUniversity of StrathclydeGlasgowUK
  2. 2.Department of Pure and Applied ChemistryUniversity of StrathclydeGlasgowUK

About the authors

Craig Jamieson earned his B.Sc. (Hons) in Chemistry at the University of Glasgow in 1996. He pursued his Ph.D. studies under Professor R Ramage at the University of Edinburgh (1999). Following postdoctoral research under the supervision of Professor S V Ley at the University of Cambridge, in 2001 he was appointed as a Principal Scientist in GlaxoSmithKline's Discovery Medicinal Chemistry group, working on a range of exploratory medicinal chemistry programmes. In 2004, Dr Jamieson joined Organon Laboratories (later Merck Research Labs) as a Group Leader in the Medicinal Chemistry Department, with responsibility for hit to clinical candidate optimisation. In August 2010, he was appointed as a John Anderson Research Lecturer in Chemical Biology, based in the Department of Pure and Applied Chemistry at the University of Strathclyde.

Keith Livingstone completed his M.Chem in Chemistry with Drug Discovery at the University of Strathclyde (2016) under the supervision of Dr Craig Jamieson. Keith remained at Strathclyde and is currently in the final year of his doctoral studies with Dr Jamieson, which have also included two short research secondments at GlaxoSmithKline Medicines Research Centre Stevenage, and with Prof Ryan Gilmour at the Westfälische Wilhelms-Universität Münster.


Bibliographic information

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