© 2020

Current Advances in Osteosarcoma

Clinical Perspectives: Past, Present and Future

  • Eugenie S. Kleinerman
  • Richard Gorlick

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1257)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Surgical Considerations and Outcomes

    1. Front Matter
      Pages 11-11
    2. Samuel Z. Grinberg, Abigail Posta, Kristy L. Weber, Robert J. Wilson
      Pages 13-29
    3. Duncan C. Ramsey, Kenneth R. Gundle
      Pages 31-41
  3. Novel Therapeutic Approaches Based on Biology

    1. Front Matter
      Pages 43-43
    2. Jonathan Gill, Pooja Hingorani, Michael Roth, Richard Gorlick
      Pages 55-66
    3. Nancy Gordon, Kumar Felix, Najat C. Daw
      Pages 67-73
    4. Simin Kiany, Douglas Harrison, Nancy Gordon
      Pages 75-83
    5. Damon R. Reed, Pooja Hingorani, Peter M. Anderson
      Pages 85-94
    6. David S. Shulman, Brian D. Crompton
      Pages 95-105
  4. Novel Immunotherapeutic Approaches

    1. Front Matter
      Pages 107-107
    2. Christopher DeRenzo, Stephen Gottschalk
      Pages 109-131
    3. Brian P. Tullius, Buhvana A. Setty, Dean A. Lee
      Pages 141-154
    4. Justin E. Markel, Ryan A. Lacinski, Brock A. Lindsey
      Pages 155-168
  5. Survivorship and Late Effects

    1. Front Matter
      Pages 179-180
    2. Anchit Bhagat, Eugenie S. Kleinerman
      Pages 181-192

About this book


This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.


bone cancer cancer metastasis osteosarcoma pediatric cancer

Editors and affiliations

  • Eugenie S. Kleinerman
    • 1
  • Richard Gorlick
    • 2
  1. 1.Department of Pediatric Research, Department of Cancer BiologyUniversity of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Division of PediatricsUniversity of Texas MD Anderson Cancer CenterHoustonUSA

About the editors

Eugenie S. Kleinerman, holds the Mary V. and John A. Reilly Distinguished Chair, and is currently Professor at the University of Texas MD Anderson Cancer Center in the Departments of Pediatrics Research and Cancer Biology. Dr. Kleinerman is internationally recognized for her scientific and clinical expertise in sarcomas, particular osteosarcoma, and for pioneering the use of a unique immunotherapy agent, liposome-encapsulated MTP-PE, for patients with newly diagnosed osteosarcoma or unresponsive relapsed osteosarcoma lung metastases. Her current research interests include developing novel ways to treat sarcoma patients by identifying new therapeutic targets, the properties that influence metastases, the efficacy of dendritic cell vaccines with and without checkpoint inhibitors for osteosarcoma lung metastases, how tumor vessels are formed in Ewing sarcoma and the use of exercise interventions to mitigate chemotherapy-induced cardiotoxicity.

Richard Gorlick, is currently the Mosbacher Pediatrics Chair of the Department of Pediatrics Patient Care, and Division Head of Pediatrics at the University of Texas MD Anderson Cancer Center. Dr. Gorlick is an internationally recognized expert in pediatric oncology and hematology, whose research and clinical work have focused on sarcomas, tumors that grow in connective tissues including bones, muscles, tendons and cartilage, understanding the mechanisms behind the development and progression of osteosarcoma, as well as targeted therapies and new drugs for childhood cancers.

Bibliographic information

  • Book Title Current Advances in Osteosarcoma
  • Book Subtitle Clinical Perspectives: Past, Present and Future
  • Editors Eugenie S. Kleinerman
    Richard Gorlick
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-43031-3
  • Softcover ISBN 978-3-030-43034-4
  • eBook ISBN 978-3-030-43032-0
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 2
  • Number of Pages XIII, 212
  • Number of Illustrations 7 b/w illustrations, 17 illustrations in colour
  • Additional Information © Springer Nature Switzerland AG 2014
  • Topics Cancer Research
    Medical Microbiology
    Cell Biology
  • Buy this book on publisher's site
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