© 2020

Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense


Table of contents

About this book


This book provides a comprehensive, organized, and concise overview of Xenobiotic Metabolic Enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. 

The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.


xenobiotics metabolic enzymes bioactivation oxidative stress antioxidant defense enzyme indivicibility

Authors and affiliations

  1. 1.Institute for Health and the Environment and Department of Biomedical SciencesUniversity at Albany, State University of New York, 5 University PlaceRensselaerUSA

About the authors

Dr. Chang-Hwei Chen is a biophysicist and professor emeritus of Biomedical Sciences at the School of Public Heath, University at Albany. He is currently a member of the Institute of Health and the Environment at the University at Albany. 

Bibliographic information

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