© 2020

New Therapies to Prevent or Cure Auditory Disorders

  • Sylvie Pucheu
  • Kelly E. Radziwon
  • Richard Salvi

Table of contents

  1. Front Matter
    Pages i-vii
  2. Shinichi Someya, Christina Rothenberger, Mi-Jung Kim
    Pages 1-21
  3. Celia Escabi, Monica Trevino, Eric Bielefeld, Edward Lobarinas
    Pages 23-50
  4. Chaitanya Mamillapalli, Asmita Dhukhwa, Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak, Vickram Ramkumar
    Pages 51-87
  5. Kelly E. Radziwon, Senthilvelan Manohar, Benjamin Auerbach, Xiaopeng Liu, Guang-Di Chen, Richard Salvi
    Pages 135-157
  6. A. Laboulais, S. Malmström, C. Dejean, M. Cardoso, T. Le Meur, L. Almeida et al.
    Pages 159-186

About this book


This volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear, exploring the idea that hair cells’ capacity to regenerate appears “repressed” in adult mammals, but that it will be possible to re-activate regeneration with an appropriate therapeutic approach. The book provides an overview of inflammatory and immune cells in the cochlear lateral wall, the pathways involved in cochlear damage, and their potential as therapeutic targets. It also describes the significant advances in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis. Finally, the book describes two new automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models.


hearing loss drug therapy noise-induced ototoxicity tinnitus hyperacusis

Editors and affiliations

  • Sylvie Pucheu
    • 1
  • Kelly E. Radziwon
    • 2
  • Richard Salvi
    • 3
  1. 1.CILcareAdvanced Solution for Drug Development in Hearing DisorderMontpellierFrance
  2. 2.Center for Hearing and DeafnessUniversity at BuffaloBuffaloUSA
  3. 3.Center for Hearing and DeafnessUniversity at BuffaloBuffaloUSA

About the editors

Dr. Sylvie Pucheu has more than 23 years' experience in academic research and the pharmaceutical industry. Dr. Pucheu is a founder and Chief Scientific Officer at CILcare, a preclinical provider in otology. Before co-founding CILcare, she led an in-vivo pharmacology group working on tinnitus and hearing loss. She has also led scientific teams at Sanofi, and has been involved in their Ethics Committee. 

Dr. Kelly E. Radziwon is a Research Assistant Professor in the Dept. of Communication Disorders and Sciences at the University of Buffalo and a member of Center for Hearing and Deafness. Her research focuses on the perceptual aspects of normal and impaired hearing in animal models.  Dr. Radziwon is an expert on tinnitus, hyperacusis, temporal processing deficits and complex auditory perception.

Dr. Richard Salvi is the co-founder and director of the University of Buffalo's Center for Hearing and Deafness. His lab focuses on multiple areas in the field of hearing and deafness. Dr. Salvi is an expert on the plasticity of the central auditory system, the effect of sensory hair cell loss on auditory function, noise-induced hearing loss, tinnitus, hyperacusis and auditory perception.

Bibliographic information

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