About this book
The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field.
This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.
The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Editors and affiliations
- Book Title HSF1 and Molecular Chaperones in Biology and Cancer
Marc Laurence Mendillo
- Series Title Advances in Experimental Medicine and Biology
- Series Abbreviated Title Adv Exp Med Biol
- DOI https://doi.org/10.1007/978-3-030-40204-4
- Copyright Information Springer Nature Switzerland AG 2020
- Publisher Name Springer, Cham
- eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
- Hardcover ISBN 978-3-030-40203-7
- Softcover ISBN 978-3-030-40206-8
- eBook ISBN 978-3-030-40204-4
- Series ISSN 0065-2598
- Series E-ISSN 2214-8019
- Edition Number 1
- Number of Pages VIII, 182
- Number of Illustrations 5 b/w illustrations, 26 illustrations in colour
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