Total Marrow Irradiation

A Comprehensive Review

  • Jeffrey Y. C. Wong
  • Susanta K. Hui

Table of contents

  1. Front Matter
    Pages i-vi
  2. Cynthia Aristei, Simonetta Saldi, Antonio Pierini, Loredana Ruggeri, Sara Piccinelli, Gianluca Ingrosso et al.
    Pages 111-121
  3. M. A. Mahé, C. Llagostera, P. Moreau, D. Antoni, P. Meyer, B. Lioure et al.
    Pages 135-143
  4. Firoozeh Sahebi
    Pages 145-154
  5. Kang-Hyun Ahn, Bulent Aydogan
    Pages 155-160
  6. Savita V. Dandapani, Jeffrey Y. C. Wong
    Pages 177-185
  7. Ashwin Shinde, Jeffrey Y. C. Wong
    Pages 187-196

About this book


This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation.  Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic.


Total Marrow Irradiation (TMI) Bone Marrow Transplantation Acute Leukemia Multiple Myeloma Intensity Modulated Radiation Therapy (IMRT) Total Body Irradiation Total Lymphoid Irradiation (TLI) Image Guided Total Marrow Irradiation Non-Hodgkin's Lymphoma

Editors and affiliations

  • Jeffrey Y. C. Wong
    • 1
  • Susanta K. Hui
    • 2
  1. 1.Department of Radiation OncologyCity Of Hope National Medical CenterDuarteUSA
  2. 2.Department of Radiation OncologyCity Of Hope National Medical CenterDuarteUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-030-38691-7
  • Online ISBN 978-3-030-38692-4
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology