This book is intended for periodontal residents and practicing periodontists who wish to incorporate the principles of moderate sedation into daily practice. A history of the development of sedation in dental practice sets the stage for understanding the need for a comprehensive preanesthetic evaluation to identify potentially reactive patients prior to treatment. Useful drugs for moderate sedation and reversal agents in the office setting are reviewed to ensure proper perioperative usage. Comprehensive airway management and rescue skills are then documented in detail so that the patient may be properly managed in the event that the sedation progresses beyond the intended level. A key aim is to equip the reader with sufficient knowledge and preparedness to overcome the patient management challenges associated with common and uncommon deviations from intraoperative norms. Finally, for those academicians interested in teaching the principles of sedation to periodontal residents, a curriculum development tool is provided to ensure comprehensive training leading to competency.