© 2020

Beyond Our Genes

Pathophysiology of Gene and Environment Interaction and Epigenetic Inheritance

  • Raffaele Teperino
  • The book highlights the relevance of human physiology and disease susceptibility

  • Can be read by both general and specialized readers

  • Studies acquired epigenetic inheritance of phenotypic setpoints


Table of contents

  1. Front Matter
    Pages i-viii
  2. The Physiology of Gene/Environment Interaction

    1. Front Matter
      Pages 1-1
    2. Immacolata Cristina Nettore, Paola Ungaro, Paolo Emidio Macchia
      Pages 3-16
    3. Silke Kiessling
      Pages 17-35
    4. Claudia Pivonello, Cristina de Angelis, Francesco Garifalos, Rosario Pivonello, Annamaria Colao
      Pages 37-51
  3. Gene-Environment Interaction and Disease Susceptibility

    1. Front Matter
      Pages 79-79
    2. Vittoria D’Esposito, Maria Rosaria Ambrosio, Giuseppe Perruolo, Michele Libutti, Pietro Formisano
      Pages 95-115
    3. Elham Assary, John Vincent, Sandra Machlitt-Northen, Rob Keers, Michael Pluess
      Pages 117-138
    4. Tamia A. Harris-Tryon, Shai Bel
      Pages 139-156
  4. Genome/Epigenome

    1. Front Matter
      Pages 157-157
    2. Martin Irmler, Daniela Kaspar, Martin Hrabě de Angelis, Johannes Beckers
      Pages 175-208
    3. Tiina Lehtiniemi, Margareeta Mäkelä, Noora Kotaja
      Pages 209-230
  5. Back Matter
    Pages 261-266

About this book


The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look.

This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy.

This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.


gene health disease environment epigenetic Inheritance complex disease susceptibility

Editors and affiliations

  • Raffaele Teperino
    • 1
  1. 1.Head of the Environmental Epigenetics GroupInstitute of Experimental Genetics & German Center for Diabetes Research (DZD), Helmholtz Zentrum München GmbH – German Research Center for Environmental HealthNeuherbergGermany

About the editors

Raffaele Teperino, PhD is based at the Institute of Experimental Genetics of the Helmholtz Research Center for Environmental Health in Munich.

Bibliographic information

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Health & Hospitals