© 2020

Interaction of Nanomaterials with the Immune System

  • James C. Bonner
  • Jared M. Brown

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-x
  2. James C. Bonner, Jared M. Brown
    Pages 1-14
  3. Dorothy J. You, Ho Young Lee, James C. Bonner
    Pages 15-34
  4. Sandeep Keshavan, Bengt Fadeel
    Pages 35-53
  5. Ryan P. Mendoza, Jared M. Brown
    Pages 55-72
  6. Rob J. Vandebriel, Henk van Loveren
    Pages 73-82
  7. Dmitri Simberg, Seyed M. Moghimi
    Pages 83-98
  8. Melisa Bunderson-Schelvan, Andrij Holian, Kevin L. Trout, Raymond F. Hamilton
    Pages 99-125
  9. Tong Zhang, Matthew J. Gaffrey, Wei-Jun Qian, Brian D. Thrall
    Pages 127-148
  10. Harri Alenius, Kai Savolainen
    Pages 149-165
  11. Hao Chen, Sara T. Humes, Navid B. Saleh, John A. Lednicky, Tara Sabo-Attwood
    Pages 167-195
  12. Barbara Rothen-Rutishauser, Barbara Drasler, Alke Petri-Fink
    Pages 197-215
  13. Back Matter
    Pages 217-223

About this book


This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.   


immune response engineered nanomaterials computational modeling immunotoxicity testing disease models fibroproliferative macrophage carcinogenesis

Editors and affiliations

  • James C. Bonner
    • 1
  • Jared M. Brown
    • 2
  1. 1.Department of Biological SciencesNorth Carolina State UniversityRaleighUSA
  2. 2.Department of Pharmaceutical Sciences Skaggs School of PharmacyUniversity of ColoradoAuroraUSA

About the editors

James C. Bonner is Professor of Toxicology at North Carolina State University. His research focuses on the fibroproliferative effects of nanomaterials in the lung, particularly in susceptible disease models. 

Jared M. Brown is Professor of Toxicology at the University of Colorado Anschutz Medical Campus. His research focuses on allergic immune responses to nanomaterials and their application in medicine.

Bibliographic information

  • Book Title Interaction of Nanomaterials with the Immune System
  • Editors James C. Bonner
    Jared M. Brown
  • Series Title Molecular and Integrative Toxicology
  • Series Abbreviated Title Molecular Integrative Toxicology
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-33961-6
  • Softcover ISBN 978-3-030-33964-7
  • eBook ISBN 978-3-030-33962-3
  • Series ISSN 2168-4219
  • Series E-ISSN 2168-4235
  • Edition Number 1
  • Number of Pages X, 223
  • Number of Illustrations 11 b/w illustrations, 5 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site
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Pharmacology & Toxicology
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