© 2019

Pertussis Infection and Vaccines

Advances in Microbiology, Infectious Diseases and Public Health Volume 12

  • Giorgio Fedele
  • Clara Maria Ausiello

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1183)

Also part of the Advances in Microbiology, Infectious Diseases and Public Health book sub series (AMIDPH, volume 1183)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Natalie Ring, Jonathan S. Abrahams, Stefan Bagby, Andrew Preston, Iain MacArthur
    Pages 1-17
  3. Alex-Mikael Barkoff, Qiushui He
    Pages 19-33
  4. Karen Scanlon, Ciaran Skerry, Nicholas Carbonetti
    Pages 35-51
  5. Joshua Gillard, Evi van Schuppen, Dimitri A. Diavatopoulos
    Pages 53-80
  6. Eleonora E. Lambert, Anne-Marie Buisman, Cécile A. C. M. van Els
    Pages 81-98
  7. Clara M. Ausiello, Françoise Mascart, Véronique Corbière, Giorgio Fedele
    Pages 99-113
  8. Daniela Hozbor
    Pages 115-126
  9. Paola Stefanelli
    Pages 127-136
  10. Ilaria Polinori, Susanna Esposito
    Pages 151-160
  11. Back Matter
    Pages 169-170

About this book


This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines.

Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replaced older-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death.

This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.


Pertussis whooping cough Pertussis infection Bordetella pertussis Pertussis Toxin Pertussis vaccines Bordetellae Pertussis diagnosis Pertussis control Pertussis management Pertussis prevention

Editors and affiliations

  • Giorgio Fedele
    • 1
  • Clara Maria Ausiello
    • 2
  1. 1.Vaccine Preventable Diseases - Reference Labs Unit, Department of Infectious DiseasesIstituto Superiore di SanitàRomeItaly
  2. 2.Former Research Director in the Department of Infectious DiseasesIstituto Superiore di SanitàRomeItaly

About the editors

Dr. Giorgio Fedele

Istituto Superiore di Sanità

Roma, Italy

Email :


Dr. Clara Maria Ausiello

Roma, Italy

Email :

Bibliographic information

  • Book Title Pertussis Infection and Vaccines
  • Book Subtitle Advances in Microbiology, Infectious Diseases and Public Health Volume 12
  • Editors Giorgio Fedele
    Clara Maria Ausiello
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-33248-8
  • Softcover ISBN 978-3-030-33251-8
  • eBook ISBN 978-3-030-33249-5
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages VIII, 170
  • Number of Illustrations 0 b/w illustrations, 10 illustrations in colour
  • Topics Medical Microbiology
    Infectious Diseases
  • Buy this book on publisher's site
Industry Sectors
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“The audience would most appropriately include individuals interested in microbiology, immunology, vaccinology, infectious disease, or public health. Readers who would benefit most would be at the graduate or professional level. … it would be a good starting point for a wide variety of learners.” (Kari Neemann, Doody's Book Reviews, February 26, 2021)