© 2020

Approaching Complex Diseases

Network-Based Pharmacology and Systems Approach in Bio-Medicine

  • Mariano Bizzarri

Part of the Human Perspectives in Health Sciences and Technology book series (HPHST, volume 2)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Mariano Bizzarri, Mirko Minini, Noemi Monti
    Pages 1-34
  3. Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras
    Pages 35-61
  4. Lucas N. Alberca, Alan Talevi
    Pages 63-75
  5. Vinicius M. Alves, Stephen J. Capuzzi, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, Anthony J. Hickey
    Pages 77-94
  6. Tomohiro Kozako, Yukihiro Itoh, Shin-ichiro Honda, Takayoshi Suzuki
    Pages 111-148
  7. Aneta Gandalovičová, Daniel Rosel, Jan Brábek
    Pages 203-211
  8. Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva
    Pages 213-244
  9. Julia Kzhyshkowska, Evgenia Grigoryeva, Irina Larionova
    Pages 245-274
  10. Sara Proietti, Andrea Pensotti, Alessandra Cucina
    Pages 275-285
  11. Paola Allavena, Manuela Liguori, Cristina Belgiovine
    Pages 287-300
  12. Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend
    Pages 301-341
  13. Deep Jyoti Bhuyan, Saumya Perera, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto et al.
    Pages 393-436
  14. Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague et al.
    Pages 437-455
  15. Matteo Bassetti, Elda Righi
    Pages 457-480

About this book


This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.


Efficiency of multi-target drugs Failing drug discovery Failure of current medical treatments Medical treatments for chronic diseases Multi-target drugs Network-based pharmacology Polypharmacology Precision medicine Systems-oriented drug design Synthesis between oriental and western medicine Systems-oriented drug design The tumor microenvironment The era of failing drug discovery

Editors and affiliations

  • Mariano Bizzarri
    • 1
  1. 1.Department of Experimental MedicineSapienza University of RomeRomeItaly

About the editors

Mariano Bizzarri PhD, M.D., is Associate Professor of Clinical Pathology in the Department of Experimental Medicine at University Sapienza, Rome (Italy). He was appointed as member of the Italian Space Agency (ASI) Scientific Committee in 2005 and he was elected President of that Committee in 2011-2014. He is a co-founder of the Italian Society for Space Biomedicine and Biochemistry (2006). Head of the Interdepartmental Systems Biology Center and member of the Space Research Interdepartmental Center of the University La Sapienza (CRAS). He is the Editor in Chief of the international journal ORGANISMS. He has authored hundreds of scientific and philosophical essays, as well as of dozen of scientific books, among which Systems Biology (Springer protocols, 2017). 

Bibliographic information

  • Book Title Approaching Complex Diseases
  • Book Subtitle Network-Based Pharmacology and Systems Approach in Bio-Medicine
  • Editors Mariano Bizzarri
  • Series Title Human Perspectives in Health Sciences and Technology
  • Series Abbreviated Title hum.Perspectives in Health Sciences and technol.
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-32856-6
  • Softcover ISBN 978-3-030-32859-7
  • eBook ISBN 978-3-030-32857-3
  • Series ISSN 2661-8915
  • Series E-ISSN 2661-8923
  • Edition Number 1
  • Number of Pages XVI, 483
  • Number of Illustrations 8 b/w illustrations, 41 illustrations in colour
  • Topics Pharmacology/Toxicology
    Systems Biology
    Philosophy of Medicine
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