• László Somsák

Part of the Topics in Heterocyclic Chemistry book series (TOPICS, volume 57)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Angeles Martín, Ernesto Suárez
    Pages 51-104
  3. Martín Soto, Humberto Rodríguez-Solla, Raquel Soengas
    Pages 171-213
  4. Damien Hazelard, Raphaël Hensienne, Jean-Bernard Behr, Philippe Compain
    Pages 261-290
  5. Back Matter
    Pages 291-295

About this book


This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.


Spiro-annulated carbohydrate Cycloaddition reactions radical chemistry spirocyclic lactones spirocyclic nucleosides Cyanhydrine and aminocyanide spirocyclization for carbohydrates

Editors and affiliations

  • László Somsák
    • 1
  1. 1.Department of Organic ChemistryUniversity of DebrecenDebrecenHungary

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