Fc Mediated Activity of Antibodies

Structural and Functional Diversity

  • Jeffrey V. Ravetch
  • Falk Nimmerjahn

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 423)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Stylianos Bournazos
    Pages 1-11
  3. Robert F. Graziano, John J. Engelhardt
    Pages 13-34
  4. Christopher Beneduce, Elma Kurtagic, Carlos J. Bosques
    Pages 35-62
  5. Taia T. Wang
    Pages 63-75
  6. Kai-Ting Shade, Michelle E. Conroy, Robert M. Anthony
    Pages 77-93
  7. Yu-mei Wen, Yan Shi
    Pages 95-118
  8. Andreas Wieland, Rafi Ahmed
    Pages 119-150

About this book


This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.


autoimmune disorders neoplastic disorders infectious disorders antibody response Fab-antigen interactions antigen recognition

Editors and affiliations

  • Jeffrey V. Ravetch
    • 1
  • Falk Nimmerjahn
    • 2
  1. 1.Department of Leonard Wagner Laboratory of Molecular Genetics and ImmunologyRockefeller UniversityNew YorkUSA
  2. 2.Department of BiologyUniversity of Erlangen-NürnbergErlangenGermany

Bibliographic information

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