This book constitutes the proceedings of the 16th International Conference on Cooperative Design, Visualization, and Engineering, CDVE 2019, held in Alcudia, Mallorca, Spain, in October 2019. The 26 revised full papers and 6 short papers presented were carefully reviewed and selected from 68 submissions. The achievement, progress and future challenges are reported in areas such as aerospace engineering, remote medical monitoring, automatic machine monitoring, cooperative personal data analytics, mobile banking, remote cooperative art performance management etc. In traditional areas such as architecture, civil engineering and construction, cooperative learning, enterprise management etc. authors also show new findings and new methodologies in their papers. This gives the readers a fresh look of how the CDVE technology is shaping our industry and daily life.